Viral and cellular MicroRNAs as determinants of viral pathogenesis and immunity

被引：383

作者：

Gottwein, Eva ^{[1
,2
]}

Cullen, Bryan R. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Ctr Virol, Durham, NC 27710 USA

来源：

CELL HOST & MICROBE | 2008年 / 3卷 / 06期

关键词：

D O I：

10.1016/j.chom.2008.05.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and cellular origin can positively or negatively influence viral replication. Viral miRNAs can directly alter host physiology, including components of the immune system, and host miRNAs can directly alter the virus life cycle. Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression.

引用

页码：375 / 387

页数：13

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