Synthesis of 2,4-diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido [4,5-b]azocine

被引：4

作者：

Taylor, EC ^{[1
]}

Dowling, JE ^{[1
]}

Bhatia, B ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 02期

关键词：

D O I：

10.1021/jo981393b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have initiated a program aimed at the synthesis of derivatives of 2,4-diamino-5,6,7,8,9,10-hexahydro-5, 9-methanopyrimido[4, 5-b]azocine (3) as potential selective inhibitors of Pneumocystis carinii DHFR. The present pap er describes a simple synthesis of 3 from 2,4,6-triaminopyrimidine and 2-cyclohexen-1-one as well as methodology for the introduction of a variety of substituents at bridgehead position C-9.

引用

页码：441 / 446

页数：6

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