Synthesis of 2,4-diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido [4,5-b]azocine

被引：4

作者：

Taylor, EC ^{[1
]}

Dowling, JE ^{[1
]}

Bhatia, B ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 02期

关键词：

D O I：

10.1021/jo981393b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have initiated a program aimed at the synthesis of derivatives of 2,4-diamino-5,6,7,8,9,10-hexahydro-5, 9-methanopyrimido[4, 5-b]azocine (3) as potential selective inhibitors of Pneumocystis carinii DHFR. The present pap er describes a simple synthesis of 3 from 2,4,6-triaminopyrimidine and 2-cyclohexen-1-one as well as methodology for the introduction of a variety of substituents at bridgehead position C-9.

引用

页码：441 / 446

页数：6

共 50 条

[1] Synthesis and bridgehead reactions of 9-substituted 5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)-ones
Taylor, EC
Bhatia, B
HETEROCYCLES, 2003, 61 : 113 - +
[2] Unexpected and facile bridgehead substitution in 5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)-ones
Taylor, EC
Dowling, JE
Schrader, T
Bhatia, B
TETRAHEDRON, 1998, 54 (33) : 9507 - 9518
[3] NEUROTROPE UND PSYCHOTROPE SUBSTANZEN .16. DERIVATE VON 5,6,7,8,9,10-HEXAHYDRO-5,9-METHANOBENZOCYCLOOKTEN UND SEINEM NIEDRIGEREN HOMOLOGEN
ADLEROVA, E
PROTIVA, M
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1967, 32 (09) : 3177 - &
[4] Synthesis of novel 5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinoline derivatives for antimicrobial and anti-oxidant evaluation
Gouhar, Rasha S.
Abou-Elmagd, Wael S. I.
El-Zahar, Magdy I.
Kamel, Mohsen M.
El-Ghonamy, Dina H.
RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (03) : 1301 - 1327
[5] Synthesis of novel 5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinoline derivatives for antimicrobial and anti-oxidant evaluation
Rasha S. Gouhar
Wael S. I. Abou-Elmagd
Magdy I. El-Zahar
Mohsen M. Kamel
Dina H. El-Ghonamy
Research on Chemical Intermediates, 2017, 43 : 1301 - 1327
[6] 5,6,7,8,9,10-hexahydro-10-hydroxy-5,9 -methano-4H-thieno[3 ,2-c]azonine
Slovak Technical Univ, Bratislava, Slovakia
Acta Crystallogr Sect C Cryst Struct Commun, Pt 7 (1825-1826):
[7] Synthesis of 2,4-diamino-pyrimido[4,5-b]indoles as inhibitors of dihydrofolate reductase
Gangjee, Aleem
Wang, Lei
Kisliuk, Roy L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
[8] SYNTHESIS OF 6-BENZYL AND 6-PHENETHYL-2,4-DIAMINO-5,6,7,8-TETRAHYDRO-PYRIMIDO[4,5-D]PYRIMIDINES
DELIA, TJ
SAMI, SM
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (05) : 929 - 931
[9] SYNTHESIS OF 1,2,3,4,6,7,8,9-OCTAHYDROPYRIMIDO-[4,5-B]QUINOLINE-2,4-DIONES
GAVRILOV, MY
KONSHIN, ME
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1989, (08): : 1114 - 1117
[10] 5,6,7,8,9,10-Hexahydro-10-hydroxy-5,9-methano-4H-thieno[3,2-c]azonine
Kozisek, J
Berkes, D
Svoboda, I
Decroix, B
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1996, 52 : 1825 - 1826

← 1 2 3 4 5 →