MicroRNAs serve as a bridge between oxidative stress and gastric cancer (Review)

被引：27

作者：

Huang, Tianhe ^{[1
]}

Wang-Johanning, Feng ^{[2
]}

Zhou, Fuling ^{[3
]}

Kallon, Herbert ^{[4
]}

Wei, Yongchang ^{[5
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Clin Oncol, Affiliated Hosp 1, Sch Med, Xian 710061, Shaanxi, Peoples R China

[2] SRI Int, Viral Oncol Program, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA

[3] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Clin Hematol, Sch Med, Xian 710004, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Coll Med, Xian 710061, Shaanxi, Peoples R China

[5] Wuhan Univ, Dept Radiat & Med Oncol, Zhongnan Hosp, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2016年 / 49卷 / 05期

基金：

中国国家自然科学基金;

关键词：

microRNAs; oxidative stress; reactive oxygen species; tumorigenesis; gastric cancer; HELICOBACTER-PYLORI INFECTION; PROMOTES CELL-PROLIFERATION; DOWN-REGULATION; TUMOR-SUPPRESSOR; MESENCHYMAL TRANSITION; SIGNALING PATHWAY; UP-REGULATION; EPIGENETIC REGULATION; ENERGY-METABOLISM; POOR-PROGNOSIS;

D O I：

10.3892/ijo.2016.3686

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer (GC) remains one of the most prevalent tumors worldwide and affects human health due to its high morbidity and mortality. Mechanisms underlying occurrence and development of GC have been widely studied. Studies have revealed reactive oxygen species (ROS) generated by cells under oxidative stress (OS) are involved in gastric tumorigenesis, and modulate expression of microRNAs (miRs). As such, miRs have been shown to be associated with OS-related GC. Given the association of OS and miRs in development of GC, this review aims to summarize the relationship between miRs and OS and their role in GC development. Serving as a link between OS and GC, miRs may offer new approaches for gaining a more in-depth understanding of mechanisms of GC and may lead to the identification of new therapeutic approaches against GC.

引用

页码：1791 / 1800

页数：10

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