Targeting SDF-1 in multiple myeloma tumor microenvironment

被引：35
作者：
Bouyssou, Juliette M. C. [1 ,2 ]
Ghobrial, Irene M. [1 ]
Roccaro, Aldo M. [1 ]
机构：
[1] Harvard Med Sch, Dept Med Oncol, Dana Farber Canc Inst, 450 Brookline Ave,HIM 246, Boston, MA 02215 USA
[2] INSERM, UMR 1163, Lab Cellular & Mol Mech Hematol Disorders & Thera, Paris, France
来源：
CANCER LETTERS | 2016年 / 380卷 / 01期
关键词：
SDF-1; CXCR4; Multiple myeloma; Microenvironment; Bone marrow; STROMAL-DERIVED FACTOR-1-ALPHA; BONE-MARROW MICROENVIRONMENT; CELL-ADHESION; MURINE MODEL; IN-VITRO; MIGRATION; EXPRESSION; CXCR4; AXIS; RECEPTOR;
D O I：
10.1016/j.canlet.2015.11.028
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Multiple myeloma (MM) is a type of B-cell malignancy that remains incurable to date. The bone marrow (BM) microenvironment plays a crucial role in MM progression. The chemokine SDF-1 (CXCL12) is an important actor of the BM microenvironment that has the ability to regulate numerous processes related to its malignant transformation during MM development. The activity of SDF-1 is mainly mediated by its specific receptor CXCR4, which is expressed at the surface of MM cells and various other BM cell types. Current treatments available for MM patients mainly target tumor cells but have limited effects on the BM microenvironment. In this context, SDF-1 and CXCR4 represent ideal targets for the normalization of the MM-supportive BM microenvironment. The present review focuses on the activity of SDF-1 in the MM BM microenvironment and the current efforts carried out to target the SDF-1/CXCR4 axis for treatment of MM. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：315 / 318
页数：4
相关论文
共 56 条
[11]   The Intricate Role of CXCR4 in Cancer [J].
Chatterjee, Samit ;
Azad, Babak Behnam ;
Nimmagadda, Sridhar .
EMERGING APPLICATIONS OF MOLECULAR IMAGING TO ONCOLOGY, 2014, 124 :31-82
[12]   The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells [J].
de Gorter, David J. J. ;
Reijmers, Rogier M. ;
Beuling, Esther A. ;
Naber, Hildegonda P. H. ;
Kuil, Annemieke ;
Kersten, Marie Jose ;
Pals, Steven T. ;
Spaargaren, Marcel .
BLOOD, 2008, 111 (07) :3364-3372
[13]  
Diamond P, 2009, J BONE MINER RES, V24, P1150, DOI [10.1359/JBMR.090210, 10.1359/jbmr.090210]
[14]   Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies [J].
Frassanito, M. A. ;
Rao, L. ;
Moschetta, M. ;
Ria, R. ;
Di Marzo, L. ;
De Luisi, A. ;
Racanelli, V. ;
Catacchio, I. ;
Berardi, S. ;
Basile, A. ;
Menu, E. ;
Ruggieri, S. ;
Nico, B. ;
Ribatti, D. ;
Fumarulo, R. ;
Dammacco, F. ;
Vanderkerken, K. ;
Vacca, A. .
LEUKEMIA, 2014, 28 (04) :904-916
[15]   Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function [J].
Garcia-Bernal, David ;
Redondo-Munoz, Javier ;
Dios-Esponera, Ana ;
Chevre, Raphael ;
Bailon, Elvira ;
Garayoa, Mercedes ;
Arellano-Sanchez, Nohemi ;
Gutierrez, Norma C. ;
Hidalgo, Andres ;
Garcia-Pardo, Angeles ;
Teixido, Joaquin .
JOURNAL OF PATHOLOGY, 2013, 229 (01) :36-48
[16]   Chemokines in cellular positioning and human disease [J].
Groom, Joanna R. .
IMMUNOLOGY AND CELL BIOLOGY, 2015, 93 (04) :328-329
[17]  
Hideshima T, 2002, MOL CANCER THER, V1, P539
[18]   The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization [J].
Hoellenriegel, Julia ;
Zboralski, Dirk ;
Maasch, Christian ;
Rosin, Nathalie Y. ;
Wierda, William G. ;
Keating, Michael J. ;
Kruschinski, Anna ;
Burger, Jan A. .
BLOOD, 2014, 123 (07) :1032-1039
[19]   Targeting the bone marrow microenvironment in multiple myeloma [J].
Kawano, Yawara ;
Moschetta, Michele ;
Manier, Salomon ;
Glavey, Siobhan ;
Goerguen, Guellue T. ;
Roccaro, Aldo M. ;
Anderson, Kenneth C. ;
Ghobrial, Irene M. .
IMMUNOLOGICAL REVIEWS, 2015, 263 (01) :160-172
[20]   Plerixafor A Review of its Use in Stem-Cell Mobilization in Patients with Lymphoma or Multiple Myeloma [J].
Keating, Gillian M. .
DRUGS, 2011, 71 (12) :1623-1647
123456