The JAK/STAT Pathway Is Involved in Synaptic Plasticity

被引：213

作者：

Nicolas, Celine S. ^{[1
]}

Peineau, Stephane ^{[1
,2
,3
]}

Amici, Mascia ^{[1
]}

Csaba, Zsolt ^{[2
,3
]}

Fafouri, Assia ^{[2
,3
]}

Javalet, Charlotte ^{[1
]}

Collett, Valerie J. ^{[1
]}

Hildebrandt, Lars ^{[4
]}

Seaton, Gillian ^{[4
]}

Choi, Sun-Lim ^{[5
,6
]}

Sim, Su-Eon ^{[5
]}

Bradley, Clarrisa ^{[5
]}

Lee, Kyungmin ^{[7
]}

Zhuo, Min ^{[5
]}

Kaang, Bong-Kiun ^{[5
,6
]}

Gressens, Pierre ^{[2
,3
]}

Dournaud, Pascal ^{[2
,3
]}

Fitzjohn, Stephen M. ^{[1
]}

Bortolotto, Zuner A. ^{[1
]}

Cho, Kwangwook ^{[4
]}

Collingridge, Graham L. ^{[1
,4
,5
]}

机构：

[1] MRC Ctr Synapt Plast, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England

[2] Robert Debre Hosp, INSERM, U676, F-75019 Paris, France

[3] Univ Paris 07, Fac Med Denis Diderot, F-75019 Paris, France

[4] Sch Clin Sci, MRC Ctr Synapt Plast, Henry Wellcome LINE, Bristol BS1 3NY, Avon, England

[5] Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul 151747, South Korea

[6] Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Natl Creat Res Initiat Ctr Memory, Seoul 151747, South Korea

[7] Kyungpook Natl Univ, Sch Med, Dept Anat, Taegu, South Korea

来源：

NEURON | 2012年 / 73卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

LONG-TERM DEPRESSION; AMPA RECEPTOR ENDOCYTOSIS; HIPPOCAMPAL-NEURONS; JAK-STAT; TYROSINE PHOSPHORYLATION; DEPENDENT ACTIVATION; KINASE INHIBITORS; JAK2/STAT3; AXIS; JANUS KINASES; IFN-GAMMA;

D O I：

10.1016/j.neuron.2011.11.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

引用

页码：374 / 390

页数：17

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