The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

被引：205

作者：

Loughran, Stephen J. ^{[1
,2
,3
]}

Kruse, Elizabeth A. ^{[1
,3
]}

Hacking, Douglas F. ^{[1
,4
]}

de Graaf, Carolyn A. ^{[1
,3
]}

Hyland, Craig D. ^{[2
]}

Willson, Tracy A. ^{[1
]}

Henley, Katya J. ^{[1
]}

Ellis, Sarah ^{[5
]}

Voss, Anne K. ^{[1
]}

Metcalf, Donald ^{[2
]}

Hilton, Douglas J. ^{[1
,3
]}

Alexander, Warren S. ^{[2
,3
]}

Kile, Benjamin T. ^{[1
,3
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Mol Med, Parkville, Vic 3050, Australia

[2] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Canc & Hematol, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[4] Royal Womens Hosp, Neonatal Serv, Carlton, Vic 3053, Australia

[5] Peter MacCallum Canc Ctr, Melbourne, Vic 3002, Australia

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 07期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/ni.1617

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.

引用

页码：810 / 819

页数：10

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