Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi

被引：47

作者：

Ni, Nanting ^{[1
]}

Chou, Han-Ting ^{[2
]}

Wang, Junfeng ^{[1
]}

Li, Minyong ^{[1
]}

Lu, Chung-Dar ^{[2
]}

Tai, Phang C. ^{[2
]}

Wang, Binghe ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, Ctr Biotechnol & Drug Design, Atlanta, GA 30302 USA

[2] Georgia State Univ, Dept Biol, Atlanta, GA 30302 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 369卷 / 02期

关键词：

quorum sensing; autoinducer-2 (AI-2); boronic acids; inhibitors;

D O I：

10.1016/j.bbrc.2008.02.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial quorum sensing plays a very important role in the regulation of biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are important research tools and potential therapeutic agents. in this paper, we describe for the first time the discovery of several boronic acids as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：590 / 594

页数：5

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