Dynamics of antibody response to CoronaVac vaccine

被引：41

作者：

Gambim Fonseca, Marcela Helena ^{[1
]}

Goebel de Souza, Tamiris de Fatima ^{[1
]}

de Carvalho Araujo, Fernanda Montenegro ^{[1
]}

Monteiro de Andrade, Luiz Odorico ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Sao Jose S-N, BR-61760000 Eusebio, Ceara, Brazil

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 05期

关键词：

CoronaVac; healthcare workers; IgG antibody; SARS-CoV-2; serology; COVID-19; SARS-COV-2; IMMUNITY;

D O I：

10.1002/jmv.27604

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CoronaVac was the first vaccine approved in Brazil for use in healthcare workers (HCWs). However, there is limited information about it, with little long-term evidence on post-vaccination antibody persistence. This study evaluated the antibody response to SARS-CoV-2 in 1237 HCWs after the first (1D), second dose (2D), and 6 months postvaccination (6mA2D) with CoronaVac. The seropositivity was 88% at 1D, increasing to 99.8% at 2D, but decreasing to 97.9% at 6mA2D, which was also observed at the analyzed antibody levels. Interestingly, the levels in females were higher than males, and we found a positive correlation with previous SARS-CoV-2 infection. Participants with comorbidities had lower levels suggesting the need to monitor for a potential booster dose. Our findings suggest that CoronaVac induced a robust antibody response that wanes significantly over time. Further longitudinal studies are needed to identify whether the antibodies will decline or plateau at a lower level.

引用

页码：2139 / 2148

页数：10

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