Protein-cross-linked polymeric materials through site-selective bioconjugation

被引：62
作者：
Esser-Kahn, Aaron P. [1 ,2 ]
Francis, Matthew B. [1 ,2 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
[2] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期
关键词：
bioconjugation; gels; hybrid materials; polymers; proteins;
D O I：
10.1002/anie.200705564
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Creating a greener future: A strategy for creating hybrid materials of polymers and proteins relies on orthogonal reactions to activate the N and C termini of a protein concurrently. The protein is then used to cross-link polymer chains and create a hydrogel (see picture). A model hybrid hydrogel containing enhanced green fluorescent protein is both biodegradable and responsive to changes in pH and temperature. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3751 / 3754
页数：4
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