NMR studies of V3 peptide complexes with antibodies suggest a mechanism for HIV-1 co-receptor selectivity

被引：0
|
作者：
Sharon, M [1 ]
Rosen, O [1 ]
Anglister, J [1 ]
机构：
[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel
来源：
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2005年 / 8卷 / 05期
关键词：
HIV-1; co-receptor; gp120; NMR of antibodies; V3;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The third variable region (V3) of the HIV-1 envelope glycoprotein gp120 is involved in gp120 binding to the chemokine receptors CCR5 and CXCR4, which serve as co-receptors in HIV-1 infection. The sequence of V3 determines whether the virus binds to CCR5 and infects predominantly macrophages (R5 virus) or to CXCR4 and infects mostly T-cells (X4 virus). This review summarizes structural information for V3 peptides in complex with HIV-1 neutralizing antibodies. Nuclear magnetic resonance studies of the V3 peptides led to the proposal of a mechanism for co-receptor selectivity. Experiments to further explore this mechanism and potential applications of V3 structural information are discussed.
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收藏
页码：601 / 612
页数：12
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