Hydrogen Bonding and Anticancer Properties of Water-Soluble Chiral p-Cymene RuII Compounds with Amino-Oxime Ligands

被引：32

作者：

Benabdelouahab, Yosra ^{[1
]}

Munoz-Moreno, Laura ^{[2
]}

Frik, Malgorzata ^{[3
,4
]}

de la Cueva-Alique, Isabel ^{[1
]}

El Amrani, Mohammed Amin ^{[5
]}

Contel, Maria ^{[3
,4
]}

Bajo, Ana M. ^{[2
]}

Cuenca, Tomas ^{[1
]}

Royo, Eva ^{[1
]}

机构：

[1] Univ Alcala de Henares, Fac Quim Biol & Ciencias Ambientales, Dept Quim Organ & Quim Inorgan, Madrid 28871, Spain

[2] Univ Alcala de Henares, Fac Med & Hlth Sci, Dept Syst Biol, Madrid 28871, Spain

[3] CUNY Brooklyn Coll, Dept Chem, Brooklyn, NY 11210 USA

[4] CUNY, Grad Ctr, Chem PhD Program, New York, NY 10016 USA

[5] Univ Abdelmalek Essaadi, Fac Sci, Dept Chim, Lab Chim Organ Appl, Tetouan, Morocco

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 13期

关键词：

Medicinal chemistry; Drug discovery; Antitumor agents; Ruthenium; Hydrogen bonds; PIANO-STOOL COMPLEXES; IN-VIVO EVALUATION; CYTOTOXIC ACTIVITY; SELF-ASSOCIATION; METAL-COMPLEXES; RUTHENIUM(II)-ARENE COMPLEXES; RUTHENIUM COMPLEXES; CRYSTAL-STRUCTURE; ALBUMIN-BINDING; ANTITUMOR DRUGS;

D O I：

10.1002/ejic.201500097

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An investigation into the effects of hydrogen bonding on the aggregation tendency of ruthenium compounds [((6)-p-cymene)Ru(NHR,NOH)Cl]Cl {R = Ph (1a), Bn (1b)} and [((6)-p-cymene)Ru((NH)-N-2(2-pic),NOH)][PF6](2) (1c), [((6)-p-cymene)Ru(NHBn,NO)Cl] (2b), and [((6)-p-cymene)Ru(NBn,(NO)-N-2)] (3b) has been performed by means of concentration-dependence H-1 NMR chemical shift and DOSY experiments. The synthesis and full characterization of new compounds 1c, [((6)-p-cymene)Ru(NPh,(NO)-N-2)] (3a) and 3b are also reported. The effect of the water-soluble ruthenium complexes 1a-c on cytotoxicity, cell adhesion, and cell migration of the androgen-independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type-I-collagen, and recovery of monolayer wounds assays, respectively. Interactions of 1a-c with DNA and human serum albumin have also been studied. Together, the properties reported herein suggest that ruthenium compounds 1a-c have considerable potential as anticancer agents against advanced prostate cancer.

引用

页码：2295 / 2307

页数：13

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