Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery

被引：76

作者：

Chakravarty, Rubel ^{[1
,2
]}

Goel, Shreya ^{[3
]}

Hong, Hao ^{[1
]}

Chen, Feng ^{[1
]}

Valdovinos, Hector F. ^{[4
]}

Hernandez, Reinier ^{[4
]}

Barnhart, Todd E. ^{[4
]}

Cai, Weibo ^{[1
,3
,4
,5
]}

机构：

[1] Univ Wisconsin, Dept Radiol, Madison, WI 53792 USA

[2] Bhabha Atom Res Ctr, Isotope Prod & Applicat Div, Bombay 400085, Maharashtra, India

[3] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[5] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53792 USA

来源：

NANOMEDICINE | 2015年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

cancer; hollow mesoporous silica nanoparticles; image-guided drug delivery; PET; positron emission tomography; theranostics; RADIOLABELED RGD PEPTIDES; INTEGRIN ALPHA(V)BETA(3); CANCER-THERAPY; BIOCOMPATIBILITY; EXPRESSION;

D O I：

10.2217/nnm.14.226

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Development of multifunctional and well-dispersed hollow mesoporous silica nanoparticles (HMSNs) for tumor vasculature targeted drug delivery and PET imaging. Materials & methods: Amine functionalized HMSNs (150-250 nm) were conjugated with a macrocyclic chelator, (S)-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triaceticacid (NOTA), PEGylated and loaded with antiangiogenesis drug, Sunitinib. Cyclo(Arg-Gly-Asp-D-Tyr-Lys) (cRGDyK) peptide was attached to the nanoconjugate and radiolabeled with Cu-64 for PET imaging. Results: Cu-64-NOTA-HMSN-PEG-cRGDyK exhibited integrin-specific uptake both in vitro and in vivo. PET results indicated approximately 8% ID/g uptake of targeted nanoconjugates in U87MG tumors, which correlated well with ex vivo and histological analyses. Enhanced tumor-targeted delivery of sunitinib was also observed. Conclusion: We successfully developed tumor vasculature targeted HMSNs for PET imaging and image-guided drug delivery.

引用

页码：1233 / 1246

页数：14

共 46 条

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