Vibrio cholerae O1 El Tor:: Identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation

被引：454

作者：

Yildiz, FH

Schoolnik, GK ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Beckman Ctr, Dept Med,Div Infect Dis & Geog Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Beckman Ctr, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 07期

关键词：

D O I：

10.1073/pnas.96.7.4028

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The rugose colony variant of Vibrio cholerae O1, biotype El Tor, is shown to produce an exopolysaccharide, EPSETr, that confers chlorine resistance and biofilm-forming capacity. EPSETr production requires a chromosomal locus, vps, that contains sequences homologous to carbohydrate biosynthesis genes of other bacterial species, Mutations within this locus yield chlorine-sensitive, smooth colony variants that are biofilm deficient, The biofilm-forming properties of EPSETr may enable the survival of V. cholerae O1 within environmental aquatic habitats between outbreaks of human disease.

引用

页码：4028 / 4033

页数：6

共 52 条

[1] GENOMIC ORGANIZATION OF THE KLEBSIELLA-PNEUMONIAE CPS REGION RESPONSIBLE FOR SEROTYPE K2 CAPSULAR POLYSACCHARIDE SYNTHESIS IN THE VIRULENT-STRAIN CHEDID [J].