Synthesis of N-aryl 2-quinolinones via intramolecular C(sp2)-H amidation of Knoevenagel products

被引：9

作者：

Luo, Laichun ^{[1
]}

Tao, Kaiqi ^{[1
]}

Peng, Xiaozhi ^{[1
]}

Hu, Chunling ^{[1
]}

Lu, Yuanfeng ^{[1
]}

Wang, Hong ^{[1
]}

机构：

[1] Hubei Univ Chinese Med, Coll Pharm, Wuhan 430065, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 106期

关键词：

ONE-POT SYNTHESIS; MERCAPTONITRILE SALTS; DERIVATIVES; CHALCONE; FUNCTIONALIZATION; ACTIVATION; ACCESS; ROUTE; ACIDS; CYCLIZATION;

D O I：

10.1039/c6ra21286g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical synthesis of N-aryl 2-quinolinones via K2S2O8-mediated intramolecular C(sp(2))-H amidation of Knoevenagel products was developed. The reaction proceeded smoothly in a biphasic solvent system composed of n-butyl acetate and H2O.

引用

页码：104463 / 104466

页数：4

共 49 条

[41] Access to Functionalized 3H-Pyrrolo[2,3-c]quinolin-4(5H)-ones and Thieno[2,3-c]quinolin-4(5H)-ones via Domino Reaction of 4-Alkynyl-3-bromoquinolin-2(1H)-ones [J].

Wang, Zhiyong ;

Xue, Lijun ;

He, Yiyi ;

Weng, Licong ;

Fang, Ling .

JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (20) :9628-9638

[42]

Wappes E. A., 2016, Angew. Chem. Int. Ed, V128, P10128

[43] Coumarin-chalcone hybrids: promising agents with diverse pharmacological properties [J].

Wei, Han ;

Ruan, Jinlan ;

Zhang, Xiaojian .

RSC ADVANCES, 2016, 6 (13) :10846-10860

[44]

Weiss M., 2014, Patent No. [WO 2014201206 Al, 2014201206]

[45] N-Hydroxyphthalimide: a new photoredox catalyst for [4+1] radical cyclization of N-methylanilines with isocyanides [J].

Yadav, Arvind K. ;

Yadav, Lal Dhar S. .

CHEMICAL COMMUNICATIONS, 2016, 52 (70) :10621-10624

[46] Radical C-H functionalization to construct heterocyclic compounds [J].

Yu, Jin-Tao ;

Pan, Changduo .

CHEMICAL COMMUNICATIONS, 2016, 52 (11) :2220-2236

[47] A catalyst-free approach to 3-thiocyanato-4H-chromen-4-ones [J].

Zhang, Xiao-Zhuan ;

Ge, Dao-Liang ;

Chen, Shan-Yong ;

Yu, Xiao-Qi .

RSC ADVANCES, 2016, 6 (70) :66320-66323

[48] Ag-catalyzed C-H/C-C bond functionalization [J].

Zheng, Qing-Zhong ;

Jiao, Ning .

CHEMICAL SOCIETY REVIEWS, 2016, 45 (16) :4590-4627

[49] Ligand-free Cu-catalyzed O-arylation of aliphatic diols [J].

Zheng, Yufen ;

Zou, Wenxing ;

Luo, Laichun ;

Chen, Jiabei ;

Lin, Songwen ;

Sun, Qi .

RSC ADVANCES, 2015, 5 (81) :66104-66108

← 1 2 3 4 5 →