Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336

被引：38
作者：
Ganguly, AK
Doll, RJ
Girijavallabhan, VM
机构：
[1] Stevens Inst Technol, Hoboken, NJ 07030 USA
[2] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
来源：
CURRENT MEDICINAL CHEMISTRY | 2001年 / 8卷 / 12期
关键词：
D O I：
10.2174/0929867013372021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to non-cytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are currently in clinical evaluation. This review focuses on FPT inhibitors in clinical trials and concentrates on the benzocycloheptapyridine class, with details on the discovery and development of SCH 66336, currently in Phase II clinical trials.
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页码：1419 / 1436
页数：18
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