IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells

被引：18

作者：

Lee, Jae Ho ^{[2
]}

Noh, Joonyong ^{[3
]}

Noh, Geunwoong ^{[1
]}

Choi, Wahn Soo ^{[4
]}

Lee, Sang Sun ^{[5
]}

机构：

[1] Chungnam Natl Univ Hosp, Dept Paediat, Div Allergy & Clin Immunol, Taejon 301721, South Korea

[2] Chungnam Natl Univ, Coll Med, Dept Paediat, Taejon, South Korea

[3] Konkuk Univ, Dept Anim Biotechnol, Coll Anim Biosci & Technol, Seoul, South Korea

[4] Konkuk Univ, Coll Med, Dept Immunol, Chungju, South Korea

[5] Hanyang Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 133791, South Korea

来源：

YONSEI MEDICAL JOURNAL | 2011年 / 52卷 / 05期

关键词：

Regulatory B cell; CD5; CD19; IL-10; CD5(+) B; LYMPHOCYTE DEVELOPMENT; B10; CELLS; ACTIVATION; AUTOIMMUNITY; EXPRESSION; RESPONSES; REQUIRES; BALANCE; ANTIGEN;

D O I：

10.3349/ymj.2011.52.5.851

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10, and Annexin V. Interestingly, IL-10-producing B cells were found to be localised within the CD19(low)CD5(+) B cell subset. Apoptotic changes were also observed mainly in CD19(low) cells among B cells. Thus, CD5(+) B cells should be classified as CD19(high) and CD19(10w) cells, and the immunological significance of CD19 for the IL-10 production by CD5(+) B cells requires further studies.

引用

页码：851 / 855

页数：5

共 19 条

[1] IL-10 produced by activated human B cells regulates CD4+ T-cell activation in vitro [J].

Bouaziz, Jean-David ;

Calbo, Sebastien ;

Maho-Vaillant, Maud ;

Saussine, Anne ;

Bagot, Martine ;

Bensussan, Armand ;

Musette, Philippe .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) :2686-2691

[2] IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus [J].

Díaz-Alderete, A ;

Crispin, JC ;

Vargas-Rojas, MI ;

Alcocer-Varela, J .

JOURNAL OF AUTOIMMUNITY, 2004, 23 (04) :379-383

[3] B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer [J].

DiLillo, David J. ;

Matsushita, Takashi ;

Tedder, Thomas F. .

YEAR IN IMMUNOLOGY 2, 2010, 1183 :38-57

[4]

Fujimoto M, 1999, J IMMUNOL, V162, P7088

[5] B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity [J].

Fujimoto, Manabu ;

Sato, Shinichi .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2007, 46 (01) :1-9

[6] IL-10 Production by B Cells Expressing CD5 with the Alternative Exon 1B [J].

Garaud, Soizic ;

Le Dantec, Christelle ;

de Mendoza, Agnes Revol ;

Mageed, Rizgar A. ;

Youinou, Pierre ;

Renaudineau, Yves .

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY, 2009, 1173 :280-285

[7] Ly1(-) (CD5(-))B cells produce interleukin (IL)-10 [J].

Gieni, RS ;

Umetsu, DT ;

DeKruyff, RH .

CELLULAR IMMUNOLOGY, 1997, 175 (02) :164-170

[8] Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis [J].

Lee, Jae Ho ;

Noh, Joonyong ;

Noh, Geunwoong ;

Kim, Hyuk Soon ;

Mun, Se Hwan ;

Choi, Wahn Soo ;

Cho, Sunheui ;

Lee, Sangsun .

CELLULAR IMMUNOLOGY, 2010, 262 (01) :44-51

[9] Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement [J].

Lee, Y ;

Haas, KM ;

Gor, DO ;

Ding, XD ;

Karp, DR ;

Greenspan, NS ;

Poe, JC ;

Tedder, TF .

JOURNAL OF IMMUNOLOGY, 2005, 175 (12) :8011-8023

[10] Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response [J].

Matsushita, T ;

Fujimoto, M ;

Hasegawa, M ;

Komura, K ;

Takehara, K ;

Tedder, TF ;

Sato, S .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (03) :812-821

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