Study of the Influence of Bone Cement Type and Mixing Method on the Bioactivity and the Elution Kinetics of Ciprofloxacin

The objectives of this study were to examine ciprofloxacin release from three trademarks of bone cements (Simplex (R), Lima (R) and Palacos (R)) and its bioactivity using as variables, the mixing method, the chemical form of the antibiotic and the antibiotic combination. The antibiotic amount released in base form represents 35% of antibiotic amount released when hydrochloride form is incorporated. Moreover, the combination (vancomycin and ciprofloxacin) shows a stronger release (132%) than hydrochloride ciprofloxacin alone. Three cements show equal drug release profile (P > 0.05). A bioactivity simulation exercise showed that until 72 hours post-surgery, ciprofloxacin concentrations in the implant would be higher than 0.1 mu g/mL in 100% of the patients. After drain removal, it is expected that bioactivity would increase since drug clearance from implant would decrease. (C) 2015 Elsevier Inc. All rights reserved.