Peroxisome-proliferator-activated receptors and cancers: Complex stories

被引：510

作者：

Michalik, L ^{[1
]}

Desvergne, B ^{[1
]}

Wahli, W ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Integrat genom, NCCR Frontiers Genet, CH-1015 Lausanne, Switzerland

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 01期

关键词：

D O I：

10.1038/nrc1254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. Through these pathways, PPARs can regulate cell proliferation, differentiation and survival, so controlling carcinogenesis in various tissues. But what are the links between each PPAR isotype and carcinogenesis and what is the relevance of these findings to human pathology and therapy?

引用

页码：61 / 70

页数：10

共 137 条

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