Spermicidal bacteriocins: Lacticin 3147 and subtilosin A

被引：36

作者：

Silkin, Lara ^{[1
]}

Hamza, Shereen ^{[2
]}

Kaufman, Susan ^{[2
]}

Cobb, Steven L. ^{[1
]}

Vederas, John C. ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[2] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2G2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.bmcl.2007.11.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spermicidal compounds that also exhibit antimicrobial properties would be extremely attractive agents as they could be used to not only prevent unwanted pregnancy but also to combat the growing prevalence of sexually transmitted infections (STI). One class of compounds that are potential candidates for development of dual-acting contraceptive products are antimicrobial peptides (AMPs). Herein, we report preliminary studies carried out to investigate the spermicidal activity of two bacteriocins, lacticin 3147 and subtilosin A, on bovine, horse/pony, boar and rat sperm. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3103 / 3106

页数：4

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