Penicillenols from Penicillium sp GQ-7, an endophytic fungus associated with Aegiceras corniculatum

被引：85

作者：

Lin, Zhen-Han ^{[1
]}

Lu, Zhen-Yu ^{[1
]}

Zhu, Tian-Hao ^{[1
]}

Fang, Yu-Chun ^{[1
]}

Gu, Qian-Qun ^{[1
]}

Zhu, Wei-Ming ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Cinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 02期

关键词：

penicillenol; endophytic fungus; Penicillium; mangrove; Aegiceras corniculatum;

D O I：

10.1248/cpb.56.217

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new tetramic acids derivatives, penicillenols A(1), A(2), B-1, B-2, C-1, and C-2 (1-6), together with citrinin, phenol A acid, phenol A, and dihydrocitrinin, were identified from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Their structures were elucidated on the basis of comprehensive spectral analysis. All the new compounds were evaluated for their cytotoxic effects on four cell lines by the NITT method. Penicillenols A(1) and B-1 showed cytotoxicities against HL-60 cell line with IC50 values of 0.76 mu M and 3.20 mu M, respectively.

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页码：217 / 221

页数：5

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