Series of Functionalized 5-(2-Arylimidazo[1,2-a]pyridin-3-yl)pyrimidine-2,4(1H,3H)-diones: A Water-Mediated Three-Component Catalyst-Free Protocol Revisited

被引：26

作者：

Brahmachari, Goutam ^{[1
]}

Nayek, Nayana ^{[1
]}

Karmakar, Indrajit ^{[1
]}

Nurjamal, Khondekar ^{[1
]}

Chandra, Swapan K. ^{[2
]}

Bhowmick, Anindita ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Lab Nat Prod & Organ Synth, Santini Ketan 731235, W Bengal, India

[2] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 13期

关键词：

ONE-POT SYNTHESIS; TRISODIUM CITRATE DIHYDRATE; MULTICOMPONENT REACTION; PHARMACEUTICAL-INDUSTRY; GABA(A) RECEPTOR; GREEN CHEMISTRY; EASY ACCESS; DERIVATIVES; EFFICIENT; ZOLPIDEM;

D O I：

10.1021/acs.joc.0c00732

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A water-mediated and catalyst-free practical method for the synthesis of a new series of pharmaceutically interesting functionalized 5-(2-arylimidazo[1,2-a]pyridin-3-yl)pyrimidine-2,4-(1H,3H)-diones has been accomplished based on a one-pot multicomponent reaction between arylglyoxal monohydrates, 2-aminopyridines/2-aminopyrimidine, and barbituric/N,N-dimethylbarbituric acids under reflux conditions. The salient features of this protocol are avoidance of any additive/catalyst and toxic organic solvents, use of water as reaction medium, clean reaction profiles, operational simplicity, ease of product isolation/purification without the aid of tedious column chromatography, good to excellent yields, and high atom-economy and low E-factor.

引用

页码：8405 / 8414

页数：10

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