Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

被引：56

作者：

Fuelsack, Simone ^{[1
]}

Rosenthal, Alevtina ^{[1
]}

Wajant, Harald ^{[1
]}

Siegmund, Daniela ^{[1
]}

机构：

[1] Univ Hosp Wurzburg, Div Mol Internal Med, Dept Internal Med 2, Wurzburg, Germany

来源：

CELL DEATH & DISEASE | 2019年 / 10卷 / 2期

关键词：

NF-KAPPA-B; NECROSIS-FACTOR RECEPTOR; INDUCED CELL-DEATH; DOMAIN KINASE RIP; ACTIVATION; PROTEIN; APOPTOSIS; FAS; CASPASE-8; UBIQUITINATION;

D O I：

10.1038/s41419-019-1396-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We evaluated redundant and receptor-specific activities of TRADD, RIPK1, and FADD in RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two of these factors. We confirmed the opposing role of FADD in TNF- and TRAIL-induced necroptosis and observed an anti-necroptotic function of TRADD. RIPK1 and TRADD act in a redundant manner in TNF-but not TRAIL-induced apoptosis. Complementary, FADD proved to be sufficient for TRAIL-but not for TNF-induced apoptosis. TRADD and RIPK1, however, redundantly mediated proinflammatory signaling in response to TNF and TRAIL. FADD deficiency sensitized more efficiently for TNFR1-mediated necroptosis than caspase-8 deficiency pointing to a caspase-8 independent inhibitory activity of FADD on TNF-induced necroptosis. Based on these characteristics, we propose a model in which the death receptor-specific activities of TRADD, RIPK1, and FADD are traced back to their hierarchically different position in TNFR1- and TRAIL death receptor signaling.

引用

页数：19

共 56 条

[1] Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed IκB Kinase Activation [J].

Blackwell, Ken ;

Zhang, Laiqun ;

Workman, Lauren M. ;

Ting, Adrian T. ;

Iwai, Kazuhiro ;

Habelhah, Hasem .

MOLECULAR AND CELLULAR BIOLOGY, 2013, 33 (10) :1901-1915

[2] Restoration of NF-κB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells [J].

Blonska, M ;

You, Y ;

Geleziunas, R ;

Lin, X .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (24) :10757-10765

[3] TRAIL receptor-2 signals apoptosis through FADD and caspase-8 [J].

Bodmer, JL ;

Holler, N ;

Reynard, S ;

Vinciguerra, P ;

Schneider, P ;

Juo, P ;

Blenis, J ;

Tschopp, J .

NATURE CELL BIOLOGY, 2000, 2 (04) :241-243

[4] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN [J].

BOLDIN, MP ;

VARFOLOMEEV, EE ;

PANCER, Z ;

METT, IL ;

CAMONIS, JH ;

WALLACH, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) :7795-7798

[5] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation [J].

Bonnet, Marion C. ;

Preukschat, Daniela ;

Welz, Patrick-Simon ;

van Loo, Geert ;

Ermolaeva, Maria A. ;

Bloch, Wilhelm ;

Haase, Ingo ;

Pasparakis, Manolis .

IMMUNITY, 2011, 35 (04) :572-582

[6] The role of TRADD in TRAIL-induced apoptosis and signaling [J].

Cao, Xiumei ;

Pobezinskaya, Yelena L. ;

Morgan, Michael J. ;

Liu, Zheng-gang .

FASEB JOURNAL, 2011, 25 (04) :1353-1358

[7] Beyond tumor necrosis factor receptor:: TRADD signaling in toll-like receptors [J].

Chen, Nien-Jung ;

Chio, Iok In Christine ;

Lin, Wen-Jye ;

Duncan, Gordon ;

Chau, Hien ;

Katz, David ;

Huang, Huey-Lan ;

Pike, Kelly A. ;

Hao, Zhenyue ;

Su, Yu-Wen ;

Yamamoto, Kazuo ;

de Pooter, Renee F. ;

Zuniga-Pflucker, Juan Carlos ;

Wakeham, Andrew ;

Yeh, Wen-Chen ;

Mak, Tak W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (34) :12429-12434

[8] FADD, A NOVEL DEATH DOMAIN-CONTAINING PROTEIN, INTERACTS WITH THE DEATH DOMAIN OF FAS AND INITIATES APOPTOSIS [J].

CHINNAIYAN, AM ;

OROURKE, K ;

TEWARI, M ;

DIXIT, VM .

CELL, 1995, 81 (04) :505-512

[9] Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells [J].

Cullen, Sean P. ;

Henry, Conor M. ;

Kearney, Conor J. ;

Logue, Susan E. ;

Feoktistova, Maria ;

Tynan, Graham A. ;

Lavelle, Ed C. ;

Leverkus, Martin ;

Martin, Seamus J. .

MOLECULAR CELL, 2013, 49 (06) :1034-1048

[10] Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death [J].

de Almagro, M. Cristina ;

Goncharov, Tatiana ;

Izrael-Tomasevic, Anita ;

Duttler, Stefanie ;

Kist, Matthias ;

Varfolomeev, Eugene ;

Wu, Xiumin ;

Lee, Wyne P. ;

Murray, Jeremy ;

Webster, Joshua D. ;

Yu, Kebing ;

Kirkpatrick, Donald S. ;

Newton, Kim ;

Vucic, Domagoj .

CELL DEATH AND DIFFERENTIATION, 2017, 24 (01) :26-37

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