Biosynthesis, degradation and pharmacological importance of the fatty acid amides

被引：108
作者：
Farrell, Emma K. [1 ]
Merkler, David J. [1 ]
机构：
[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA
来源：
DRUG DISCOVERY TODAY | 2008年 / 13卷 / 13-14期
关键词：
D O I：
10.1016/j.drudis.2008.02.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine (anandamide) and oleamide, has generated a great deal of excitement and stimulated considerable research. However, anandamide and oleamide are merely the best-known and best-understood members of a much larger family of biologically occurring fatty acid amides. In this review, we will outline which fatty acid amides have been isolated from mammalian sources, detail what is known about how these molecules are made and degraded in vivo, and highlight their potential for the development of novel therapeutics.
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页码：558 / 568
页数：11
相关论文
共 123 条
[1]   IDENTIFICATION OF FATTY-ACID AMIDES IN HUMAN-PLASMA [J].
ARAFAT, ES ;
TRIMBLE, JW ;
ANDERSEN, RN ;
DASS, C ;
DESIDERIO, DM .
LIFE SCIENCES, 1989, 45 (18) :1679-1687
[2]   N-ACETYL-L-ASPARAGINE IN HUMAN BRAIN [J].
AUDITORE, JV ;
WADE, LH .
NEUROPHARMACOLOGY, 1972, 11 (03) :385-+
[3]  
BACHUR NR, 1966, J BIOL CHEM, V241, P1308
[4]   The sleep inducing factor oleamide is produced by mouse neuroblastoma cells [J].
Bisogno, T ;
Sepe, N ;
DePetrocellis, L ;
Mechoulam, R ;
DiMarzo, V .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 239 (02) :473-479
[5]   N-acyl-dopamines:: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo [J].
Bisogno, T ;
Melck, D ;
Bobrov, MY ;
Gretskaya, NM ;
Bezuglov, VV ;
De Petrocellis, L ;
Di Marzo, V .
BIOCHEMICAL JOURNAL, 2000, 351 (03) :817-824
[6]   Evaluation of urinary acylglycines by electrospray tandem mass spectrometry in mitochondrial energy metabolism defects and organic acidurias [J].
Bonafé, L ;
Troxler, H ;
Kuster, T ;
Heizmann, CW ;
Chamoles, NA ;
Burlina, AB ;
Blau, N .
MOLECULAR GENETICS AND METABOLISM, 2000, 69 (04) :302-311
[7]   Mechanistic studies of melanogenesis:: the influence of N-substitution on dopamine quinone cyclization [J].
Borovansky, J ;
Edge, R ;
Land, EJ ;
Navaratnam, S ;
Pavel, S ;
Ramsden, CA ;
Riley, PA ;
Smit, NPM .
PIGMENT CELL RESEARCH, 2006, 19 (02) :170-178
[8]   Oxidative metabolism of anandamide [J].
Burstein, SH ;
Rossetti, RG ;
Yagen, B ;
Zurier, RB .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2000, 61 (1-2) :29-41
[9]   Biochemical properties of recombinant human and mouse N-acetylglutamate synthase [J].
Caldovic, L ;
Lopez, GY ;
Haskins, N ;
Panglao, M ;
Shi, DS ;
Morizono, H ;
Tuchman, M .
MOLECULAR GENETICS AND METABOLISM, 2006, 87 (03) :226-232
[10]  
Caldwell J., 1980, EXTRAHEPATIC METABOL, P453
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