Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats

被引：7

作者：

Wu, Wen-Yu ^{[1
]}

Zhong, Yue ^{[1
]}

Lu, Yu-Ting ^{[1
]}

Sun, Ying ^{[1
]}

Li, Nian-Guang ^{[1
]}

Shi, Zhi-Hao ^{[1
,2
]}

Dong, Ze-Xi ^{[1
]}

Gu, Ting ^{[1
]}

Xue, Xin ^{[1
]}

Fang, Fang ^{[1
]}

Li, He-Min ^{[1
]}

Tang, Yu-Ping ^{[1
,3
]}

Duan, Jin-Ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Jiangsu Key Lab High Technol Res TCM Formulae, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 211198, Jiangsu, Peoples R China

[3] Shaanxi Univ Chinese Med, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Xianyang 712083, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 12期

关键词：

6-O-methyl-scutellarein; scutellarin; cerebral ischemia; BCCAO; protective effect; SPATIAL COGNITION; BRAIN-INJURY; ISCHEMIA; SCUTELLARIN; MECHANISMS; TRANSIENT; GLUTAMATE;

D O I：

10.1080/10286020.2017.1383396

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia. [GRAPHICS] .

引用

页码：1167 / 1181

页数：15

共 25 条

[1]

[Anonymous], 2002, J PHARM PRACT

[2] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].