Amoebapores

被引：124
作者：
Leippe, M
机构：
[1] Department of Molecular Biology, Bernhard Nocht Inst. for Trop. Med., 20359 Hamburg
来源：
PARASITOLOGY TODAY | 1997年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0169-4758(97)01038-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The enormous cytolytic potential of Entamoeba histolytica appeals to parasitologists and immunologists because it kills target cells in a contact-dependent reaction resembling that of cytotoxic lymphocytes. In this review, Matthias Leippe summarizes what is currently known about a family of pore-forming peptides termed 'amoebapores', to which the cytolytic effect has been attributed, and describes the structural and functional properties of these potent factors, as well as their structure-activity relationships. Finally, a comparison is made with effector molecules of the mammalian defensive system.
引用
收藏
页码：178 / 183
页数：6
相关论文
共 41 条
[1]   PLASMA-MEMBRANE OF ENTAMOEBA-HISTOLYTICA [J].
ALEY, SB ;
SCOTT, WA ;
COHN, ZA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 152 (02) :391-404
[2]   NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY [J].
ANDERSSON, M ;
GUNNE, H ;
AGERBERTH, B ;
BOMAN, A ;
BERGMAN, T ;
SILLARD, R ;
JORNVALL, H ;
MUTT, V ;
OLSSON, B ;
WIGZELL, H ;
DAGERLIND, A ;
BOMAN, HG ;
GUDMUNDSSON, GH .
EMBO JOURNAL, 1995, 14 (08) :1615-1625
[3]   AN AMPHIPATHIC HELICAL MOTIF COMMON TO TUMOUROLYTIC POLYPEPTIDE NK-LYSIN AND PULMONARY SURFACTANT POLYPEPTIDE SP-B [J].
ANDERSSON, M ;
CURSTEDT, T ;
JORNVALL, H ;
JOHANSSON, J .
FEBS LETTERS, 1995, 362 (03) :328-332
[4]   PORE-FORMING PEPTIDE OF ENTAMOEBA-HISTOLYTICA - SIGNIFICANCE OF POSITIVELY CHARGED AMINO-ACID-RESIDUES FOR ITS MODE OF ACTION [J].
ANDRA, J ;
LEIPPE, M .
FEBS LETTERS, 1994, 354 (01) :97-102
[5]   Shortened amoebapore analogs with enhanced antibacterial and cytolytic activity [J].
Andra, J ;
Berninghausen, O ;
Wulfken, J ;
Leippe, M .
FEBS LETTERS, 1996, 385 (1-2) :96-100
[6]   PHAGOLYSOSOMAL ESCAPE BY INTRACELLULAR PATHOGENS [J].
ANDREWS, NW ;
WEBSTER, P .
PARASITOLOGY TODAY, 1991, 7 (12) :335-340
[7]   ENTAMOEBA-HISTOLYTICA AS A MODEL FOR THE PRIMITIVE EUKARYOTIC CELL [J].
BAKKERGRUNWALD, T ;
WOSTMANN, C .
PARASITOLOGY TODAY, 1993, 9 (01) :27-31
[8]   INTERACTIONS BETWEEN MEMBRANES AND CYTOLYTIC PEPTIDES [J].
BERNHEIMER, AW ;
RUDY, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 864 (01) :123-141
[9]   Molecular modeling of amoebapore and NK-lysin: A four-alpha-helix bundle motif of cytolytic peptides from distantly related organisms [J].
Dandekar, T ;
Leippe, M .
FOLDING & DESIGN, 1997, 2 (01) :47-52
[10]   ANIONIC PHOSPHOLIPIDS AND PROTEIN TRANSLOCATION [J].
DEKRUIJFF, B .
FEBS LETTERS, 1994, 346 (01) :78-82
12345