Exploiting Oncogenic Drivers along the CCNG1 Pathway for Cancer Therapy and Gene Therapy

被引:17
作者
Al-Shihabi, Ahmad [1 ]
Chawla, Sant P. [1 ]
Hall, Frederick L. [2 ]
Gordon, Erlinda M. [1 ,2 ,3 ]
机构
[1] Sarcoma Oncol Ctr, Canc Ctr Southern Calif, 2811 Wilshire Blvd,Suite 414, Santa Monica, CA 90403 USA
[2] Delta Next Gene LLC, Santa Monica, CA 90403 USA
[3] Aveni Fdn, Santa Monica, CA 90403 USA
关键词
CYCLIN G1; REXIN-G; C-MYC; P53; TARGET; TUMOR;
D O I
10.1016/j.omto.2018.11.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:122 / 126
页数:5
相关论文
共 25 条
[1]   Hepatitis B virus X protein mediated suppression of miRNA-122 expression enhances hepatoblastoma cell proliferation through cyclin G1-p53 axis [J].
Bandopadhyay, Manikankana ;
Sarkar, Neelakshi ;
Datta, Sibnarayan ;
Das, Dipanwita ;
Pal, Ananya ;
Panigrahi, Rajesh ;
Banerjee, Arup ;
Panda, Chinmay K. ;
Das, Chandrima ;
Chakrabarti, Shekhar ;
Chakravarty, Runu .
INFECTIOUS AGENTS AND CANCER, 2016, 11
[2]  
Bruckner H., 2010, J CLIN ONCOL, V28, P4149
[3]  
Chawla S.P., 2016, SARCOMA RES INT, V3, P1
[4]   Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer [J].
Chawla, Sant P. ;
Chua, Victoria S. ;
Fernandez, Lita ;
Quon, Dorris ;
Blackwelder, William C. ;
Gordon, Erlinda M. ;
Hall, Frederick L. .
MOLECULAR THERAPY, 2010, 18 (02) :435-441
[5]   Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma [J].
Chawla, Sant P. ;
Chua, Victoria S. ;
Fernandez, Lita ;
Quon, Doris ;
Saralou, Andreh ;
Blackwelder, William C. ;
Hall, Frederick L. ;
Gordon, Erlinda M. .
MOLECULAR THERAPY, 2009, 17 (09) :1651-1657
[6]   MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells [J].
Fornari, Francesca ;
Gramantieri, Laura ;
Giovannini, Catia ;
Veronese, Angelo ;
Ferracin, Manuela ;
Sabbioni, Silvia ;
Calin, George Adrian ;
Grazi, Gian Luca ;
Croce, Carlo Maria ;
Tavolari, Simona ;
Chieco, Pasquale ;
Negrini, Massimo ;
Bolondi, Luigi .
CANCER RESEARCH, 2009, 69 (14) :5761-5767
[7]   Phase I trial of a pathotropic retroviral vector expressing a cytocidal cyclin G1 construct (rexin-G) in patients with advanced pancreatic cancer [J].
Galanis, Evanthia ;
Carlson, Stephanie K. ;
Foster, Nathan R. ;
Lowe, Val ;
Quevedo, Fernando ;
McWilliams, Robert R. ;
Grothey, Axel ;
Jatoi, Aminah ;
Alberts, Steven R. ;
Rubin, Joseph .
MOLECULAR THERAPY, 2008, 16 (05) :979-984
[8]  
Gerber DE, 2008, AM FAM PHYSICIAN, V77, P311
[9]   Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad-spectrum cancer gene therapy - A review of molecular mechanisms for oncologists [J].
Gordon, Erlinda M. ;
Ravicz, Joshua R. ;
Liu, Seiya ;
Chawla, Sant P. ;
Hall, Frederick L. .
MOLECULAR AND CLINICAL ONCOLOGY, 2018, 9 (02) :115-134
[10]   Cyclin g1 is a target of miR-122a, a MicroRNA frequently down-regulated in human hepatocellular carcinoma [J].
Gramantieri, Laura ;
Ferracin, Manuela ;
Fornari, Francesca ;
Veronese, Airtgelo ;
Sabbioni, Silvia ;
Liu, Chang-Gong ;
Calin, George A. ;
Giovannini, Catia ;
Ferrazzi, Eros ;
Grazi, Gian Luca ;
Croce, Carlo M. ;
Bolondi, Luigi ;
Negrini, Massimo .
CANCER RESEARCH, 2007, 67 (13) :6092-6099