ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

被引：44

作者：

Hueso, Miguel ^{[1
,2
]}

Mallen, Adrian ^{[2
]}

Sune-Pou, Marc ^{[3
]}

Aran, Josep M. ^{[4
]}

Sune-Negre, Josep M. ^{[3
]}

Navarro, Estanislao ^{[3
]}

机构：

[1] Hosp Univ Bellvitge, Dept Nephrol, Lhospitalet De Llobregat 08907, Spain

[2] IDIBELL, Inst dInvest Biomed Bellvitge, Nephrol & Renal Transplantat Grp, Infect Dis & Transplantat Program, Lhospitalet De Llobregat 08907, Spain

[3] Univ Barcelona, Fac Pharm & Food Sci, Pharm & Pharmaceut Technol & Phys Chem Dept, Av. Joan XXIII,27-31, Barcelona 08028, Spain

[4] IDIBELL, Inst Invest Biomed Bellvitge, Immunoinflammatory Processes & Gene Therapeut Lab, Lhospitalet De Llobregat 08908, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

ncRNAs; nanotechnology; oligonucleotide therapy; delivery vehicles; nanoparticles; IN-VITRO; GOLD NANOPARTICLES; CANCER; SIZE; RNA; NANOCARRIERS; EXOSOMES; SYSTEM; CELLS;

D O I：

10.3390/ijms222111596

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target " and "off-target " side effects. In this "ncRNA in therapeutics " issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.

引用

页数：15

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