Towards a super-resolution structured illumination microscope based on an array of nanoLEDs

被引：3

作者：

Franch, Nil ^{[1
]}

Canals, Joan ^{[1
]}

Moro, Victor ^{[1
]}

Alonso, Oscar ^{[1
]}

Moreno, Sergio ^{[1
]}

Vila, Anna ^{[1
]}

Daniel Prades, Joan ^{[1
]}

Guelink, Jan ^{[2
]}

Wasisto, Hutomo Suryo ^{[2
]}

Waag, Andreas ^{[2
]}

Dieguez, Angel ^{[1
]}

机构：

[1] Univ Barcelona, Dept Elect & Biomed Engn, Barcelona, Spain

[2] Univ Technol Braunschweig, Inst Semicond Technol, Braunschweig, Germany

来源：

NOVEL OPTICAL SYSTEMS, METHODS, AND APPLICATIONS XXII | 2019年 / 11105卷

关键词：

Microscopy; lensless; shadow imaging; superresolution; SPAD; nanoLED; microscope;

D O I：

10.1117/12.2529258

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

This work presents a first prototype for a new approach to microscopy: a system basing its resolving power on the light emitters instead of the sensors, without using lenses. This new approach builds on the possibility of making LEDs smaller than current technology sensors, offering a new approach to microscopy we plan on developing towards super-resolution. The microscope consists on a SPAD based camera, a 8x8 LED array with 5x5 mu m LEDs distributed with a pitch of 10 mu m, and discrete driving electronics to control them. We present simulations of the system, as well as the first microscope prototype implementing the method, and the results obtained through it.

引用

页数：7

共 15 条

[1]

Bermudez-Hernandez K., 2017, SCI REP

[2]

Betzig E., 2006, SCIENCE

[3]

Born M., 1999, PRINCIPLES OPTICS

[4]

Godin A. G., 2014, BIOPHYS J

[5]

Klar T. A., 1999, OPT LETT

[6]

Kwak Y. H., 2014, J MICROBIOL METHODS

[7]

Ma H., 2017, SCI REP

[8]

Ozcan A., 2016, ANN REV BIOMED ENG

[9] Malaria Diagnosis Using a Mobile Phone Polarized Microscope [J].

Pirnstill, Casey W. ;

Cote, Gerard L. .

SCIENTIFIC REPORTS, 2015, 5

[10]

Restrepo J. F., 2012, OPT LETT

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