Monoterpene indole alkaloids from Melodinus cochinchinensis (Lour.) Merr.

被引：5
作者：
Wang, Xiao-Feng [1 ,2 ]
Wei, Ren-Jie [1 ,2 ]
Fang, Qiang-Qiang [1 ,2 ]
He, Wan-Ying [1 ,2 ]
Jiang, Kun [1 ]
Qu, Shi-Jin [1 ]
Tan, Jun-Jie [1 ]
Tan, Chang-Heng [1 ,2 ]
机构：
[1] Chinese Acad Sci, Nat Prod Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
来源：
FITOTERAPIA | 2022年 / 157卷
关键词：
FRUITS;
D O I：
10.1016/j.fitote.2021.105118
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Melodicochinines A - D (1-4), four new monoterpene indole alkaloids (MIAs), along with 21 known ones, were isolated from the stems and twigs of Melodinus cochinchinensis. Their structures were elucidated on the basis of extensive spectroscopic analysis. A ubiquitin-rhodamine 110 assay showed that 11-methyloxytabersonine had potential inhibitory effect against ubiquitin-specific protease 7 (USP7).
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页数：4
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