Metabolomics-based promising candidate biomarkers and pathways in Alzheimer's disease

被引：10

作者：

Kang, Jian ^{[1
]}

Lu, Jingli ^{[1
]}

Zhang, Xiaojian ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou 450052, Henan, Peoples R China

来源：

PHARMAZIE | 2015年 / 70卷 / 05期

关键词：

MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; MASS-SPECTROMETRY; CHOLESTEROL-METABOLISM; LIPID-PEROXIDATION; APOLIPOPROTEIN-E; SENILE PLAQUES; BRAIN; PLASMA; GLYCEROPHOSPHOLIPIDS;

D O I：

10.1691/ph.2015.4859

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pathologically, loss of synapses and neurons, extracellular senile plaques and intracellular neurofibrillary tangles (NFTs) are observed in the brains of patients with Alzheimer's disease (AD). These features are associated with changes A beta (amyloid beta) 40, A beta 42, total tau and phosphorylated tau (p-tau), which are as definitely bionnarkers for severe AD state. However, biomarkers. for effectively diagnosing AD in the pre-clinical state for directing therapeutic strategies are lacking. Metabolic profiling as a powerful tool to identify new blomarkers is receiving increasing attention in AD. This review will focus on metabolomics-based detection of promising candidate biomarkers and pathways in AD to facilitate the discovery of new medicines and disease pathways.

引用

页码：277 / 282

页数：6

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