Plasmodium falciparum:: Characterization of a late asexual stage Golgi protein containing both ankyrin and DHHC domains

被引：12

作者：

Seydel, KB

Gaur, D

Aravind, L

Subramanian, G

Miller, LH ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA

[2] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[3] Human Genome Sci, Rockville, MD USA

来源：

EXPERIMENTAL PARASITOLOGY | 2005年 / 110卷 / 04期

关键词：

malaria; Plasmodium; palmitoylation; ankyrin;

D O I：

10.1016/j.exppara.2005.03.030

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Proteins containing the DHHC motif have been shown to function as palmitoyl transferases. The palmitoylation of proteins has been shown to play an important role in the trafficking of proteins to the proper subcellular location. Herein, we describe a protein containing both ankyrin domains and a DHHC domain that is present in the Golgi of late schizonts of P.falciparum. The timing of expression as well as the location of this protein suggests that it may play an important role in the sorting of proteins to the apical organelles during the development of the asexual stage of the parasite. Published by Elsevier Inc.

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页码：389 / 393

页数：5

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