Post-transplant lymphoproliferative disorder after solid-organ transplant in children

被引：18
作者：
Absalon, Michael J. [1 ]
Khoury, Ruby A. [1 ]
Phillips, Christine L. [1 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, 3333 Burnet Ave,MLC 7018, Cincinnati, OH 45229 USA
来源：
SEMINARS IN PEDIATRIC SURGERY | 2017年 / 26卷 / 04期
关键词：
PTLD; Post-transplant lymphoproliferative disorder; EPSTEIN-BARR-VIRUS; PEDIATRIC LIVER-TRANSPLANTATION; CYTOTOXIC T-CELLS; BONE-MARROW INVOLVEMENT; LOW-DOSE CHEMOTHERAPY; NON-HODGKIN LYMPHOMAS; QUALITY-OF-LIFE; RISK-FACTORS; BRENTUXIMAB VEDOTIN; PROGNOSTIC-FACTORS;
D O I：
10.1053/j.sempedsurg.2017.07.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The post-transplant lymphoproliferative disorders (PTLD) are a diverse group of potentially life-threatening conditions affecting organ transplant recipients. PTLD arises in the setting of an attenuated host immunologic system that is manipulated to allow a foreign graft but then fails to provide adequate immune surveillance of transformed malignant or premalignant lymphocytes. The diversity of biological behavior and clinical presentation makes for a challenging clinical situation for those involved in the care of children with PTLD occurring after solid-organ transplantation. This review details a large transplant center's multidisciplinary approach to monitoring for PTLD and systematic approach to intervention, which has been essential for early recognition and successful treatment. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：257 / 266
页数：10
相关论文
共 139 条
[91]   Decreasing Incidence of Symptomatic Epstein-Barr Virus Disease and Posttransplant Lymphoproliferative Disorder in Pediatric Liver Transplant Recipients: Report of the Studies of Pediatric Liver Transplantation Experience [J].
Narkewicz, Michael R. ;
Green, Michael ;
Dunn, Stephen ;
Millis, Michael ;
McDiarmid, Susan ;
Mazariegos, George ;
Anand, Ravinder ;
Yin, Wanrong .
LIVER TRANSPLANTATION, 2013, 19 (07) :730-740
[92]  
National Comprehensive Cancer Network, B CELL LYMP VERS 3 2
[93]  
National Guideline C. National Guideline Clearinghouse (NGC), 2012, GUID SUMM EV BAS CLI
[94]   Posttransplant lymphoproliferative disease in pediatric liver transplantation - Interplay between primary Epstein-Barr virus infection and immunosuppresion [J].
Newell, KA ;
Alonso, EM ;
Whitington, PF ;
Bruce, DS ;
Millis, JM ;
Piper, JB ;
Woodle, ES ;
Kelly, SM ;
Koeppen, H ;
Hart, J ;
Rubin, CM ;
Thistlethwaite, JR .
TRANSPLANTATION, 1996, 62 (03) :370-375
[95]   Virus-specific T-cell banks for 'off the shelf' adoptive therapy of refractory infections [J].
O'Reilly, R. J. ;
Prockop, S. ;
Hasan, A. N. ;
Koehne, G. ;
Doubrovina, E. .
BONE MARROW TRANSPLANTATION, 2016, 51 (09) :1163-1172
[96]   Salvage chemotherapy for refractory or relapsed post-transplant lymphoproliferative disorder in patients after solid organ transplantation with a combination of carboplatin and etoposide [J].
Oertel, SH ;
Papp-Váry, M ;
Anagnostopoulos, I ;
Hummel, MW ;
Jonas, S ;
Riess, HB .
BRITISH JOURNAL OF HAEMATOLOGY, 2003, 123 (05) :830-835
[97]   Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD) [J].
Oertel, SHK ;
Verschuuren, E ;
Reinke, P ;
Zeidler, K ;
Papp-Váry, M ;
Babel, N ;
Trappe, RU ;
Jonas, S ;
Hummel, M ;
Anagnostopoulos, I ;
Dörken, B ;
Riess, HB .
AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (12) :2901-2906
[98]   Checkpoint inhibitors in hematological malignancies [J].
Ok, Chi Young ;
Young, Ken H. .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10
[99]  
Orjuela M, 2003, CLIN CANCER RES, V9, p3945S
[100]   Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines [J].
Parker, Anne ;
Bowles, Kristin ;
Bradley, J. Andrew ;
Emery, Vincent ;
Featherstone, Carrie ;
Gupte, Girish ;
Marcus, Robert ;
Parameshwar, Jayan ;
Ramsay, Alan ;
Newstead, Charles .
BRITISH JOURNAL OF HAEMATOLOGY, 2010, 149 (05) :675-692
567891011121314