Exploration of Central Nervous System Activities of Caryota Urens ethanolic Leaf Extract on Neurological Disorders in Experimental Animal Models

Central nervous system plays a vital role in the physiological organization of the completely human body. In modern world, everyday people suffered by depression, anxiety, epilepsy and restlessness due to stress. According to WHO report, about 450 million people suffer from a mental or behavioural disorder. Use of herbal medicine has been increased due to its safety and plays vital role in CNS disorders. The urens is the principle phytoconstituent present in the Caryota urens, and others are flavonoids, phenolic compounds, amino acids, alkaloids, proteins and carbohydrate which are medicinally important and responsible for treating various illness including neurological disorders. The study was conducted with an aim, to assess the influence of Caryota urens leaf extract on CNS by evaluating its effect on various neurological disorders in experimental animal models. The dried leaves of Caryota urens was extracted by maceration process using ethanol as solvent. The CNS activities of dried ethanolic leaf extract of Caryota urens (200 and 400mg/kg) were evaluated using various models for Antidepressant activity, Anxiolytic activity, Locomotor activity, Muscle relaxant activity and Anti-convulsant activity. The ELECU dose dependently increase the number of head dips, which indicate, that the leaves of Caryota urens shows antidepressant activity. The elevated plus maze is considered to be an etiologically valid animal model of anxiety. The number of entries and time spent in the open arms have been found to be increased by anxiolytics and reduced by anxiogenic agents. The reference standard diazepam significantly increase both the number of entries and time spent in open arm. Similar effect was produced by the ELECU in the open arm that indicates the anxiolytic activity of ELECU. In the presence study we concluded that the ethanolic leaf extract of Caryota urens possess significant antidepressant, anxiolytic, locomotor, muscle relaxant and anticonvulsant activities in mice.