Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

被引：45

作者：

Bhoo-Pathy, Nirmala ^{[1
,2
,3
]}

Peeters, Petra H. M. ^{[1
,4
]}

Uiterwaal, Cuno S. P. M. ^{[1
]}

Bueno-de-Mesquita, H. Bas ^{[2
,4
,5
,6
]}

Bulgiba, Awang M. ^{[2
]}

Bech, Bodil Hammer ^{[7
]}

Overvad, Kim ^{[7
]}

Tjonneland, Anne ^{[8
]}

Olsen, Anja ^{[8
]}

Clavel-Chapelon, Francoise ^{[9
,10
]}

Fagherazzi, Guy ^{[9
,10
]}

Perquier, Florence ^{[9
,10
]}

Teucher, Birgit ^{[11
]}

Kaaks, Rudolf ^{[11
]}

Schuetze, Madlen ^{[12
]}

Boeing, Heiner ^{[12
]}

Lagiou, Pagona ^{[13
]}

Orfanos, Philippos ^{[13
]}

Trichopoulou, Antonia ^{[13
,14
]}

Agnoli, Claudia ^{[15
]}

Mattiello, Amalia ^{[16
]}

Palli, Domenico ^{[17
]}

Tumino, Rosario ^{[18
]}

Sacerdote, Carlotta ^{[19
,20
]}

van Duijnhoven, Franzel J. B. ^{[5
,21
]}

Braaten, Tonje ^{[22
]}

Lund, Eiliv ^{[22
]}

Skeie, Guri ^{[22
]}

Redondo, Maria-Luisa ^{[23
]}

Buckland, Genevieve ^{[24
]}

Sanchez Perez, Maria Jose ^{[25
,26
]}

Chirlaque, Maria-Dolores ^{[26
,27
]}

Ardanaz, Eva ^{[26
,28
]}

Amiano, Pilar ^{[26
,29
]}

Wirfalt, Elisabet ^{[30
]}

Wallstrom, Peter ^{[30
]}

Johansson, Ingegerd ^{[31
]}

Nilsson, Lena Maria ^{[32
]}

Khaw, Kay-Tee ^{[33
]}

Wareham, Nick ^{[34
]}

Allen, Naomi E. ^{[35
]}

Key, Timothy J. ^{[35
]}

Rinaldi, Sabina ^{[36
]}

Romieu, Isabelle ^{[36
]}

Gallo, Valentina ^{[4
,37
]}

Riboli, Elio ^{[4
]}

van Gils, Carla H. ^{[1
]}

机构：

[1] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands

[2] Univ Malaya, Fac Med, Julius Ctr, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[3] Kuala Lumpur Hosp, Natl Clin Res Ctr, Minist Hlth, Kuala Lumpur, Malaysia

[4] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[5] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[6] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[7] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[8] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark

[9] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, INSERM,U1018, F-94805 Villejuif, France

[10] Univ Paris 11, UMRS 1018, F-94807 Villejuif, France

[11] German Canc Res Ctr, Dept Canc Epidemiol, Heidelberg, Germany

[12] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[13] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[14] Hellen Hlth Fdn, GR-11527 Athens, Greece

[15] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, I-20133 Milan, Italy

[16] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy

[17] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[18] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[19] HuGeF Fdn, Turin, Italy

[20] CPO Piemonte, Turin, Italy

[21] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[22] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[23] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[24] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[25] Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Granada Granada Ibs, Granada, Spain

[26] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[27] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[28] Navarre Publ Hlth Inst, Pamplona, Spain

[29] Inst Invest Sanitaria, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[30] Lund Univ, Dept Clin Sci Malmo, Nutr Epidemiol, Malmo, Sweden

[31] Umea Univ, Dept Odontol, Umea, Sweden

[32] Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden

[33] Univ Cambridge, Sch Clin Med, Cambridge, England

[34] MRC, Epidemiol Unit, Cambridge, England

[35] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[36] Int Agcy Res Canc, Lyon, France

[37] Queen Mary Univ London, Barts & London Sch Med, Ctr Primary Care & Publ Hlth, London, England

来源：

BREAST CANCER RESEARCH | 2015年 / 17卷

基金：

英国医学研究理事会;

关键词：

SEX-HORMONE CONCENTRATIONS; CAFFEINE CONSUMPTION; PREMENOPAUSAL; WOMEN; METAANALYSIS; CALIBRATION; POPULATION; VALIDITY;

D O I：

10.1186/s13058-015-0521-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P-trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P-trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.

引用

页数：12

共 43 条

[21]

LEVITON A, 1994, EPIDEMIOLOGY, V5, P537

[22] Coffee consumption modifies risk of estrogen-receptor negative breast cancer [J].