PHASE 1 TRIAL WITH CONTROLLED HUMAN MALARIA INFECTION: AN OPEN LABEL DOSE-ESCALATION SAFETY, REACTOGENICITY, IMMUNOGENICITY, AND EFFICACY STUDY OF THE CANDIDATE VACCINE PLASMODIUM FALCIPARUM MALARIA PROTEIN (FMP012), AN E-COLI-EXPRESSED CELL-TRAVERSAL PROTEIN FOR OOKINETES AND SPOROZOITES (PFCELTOS), ADMINISTERED INTRAMUSCULARLY WITH THE ADJUVANT SYSTEM AS01B IN HEALTHY, MALARIA-NAIVE ADULTS

被引：0

作者：

Bennett, Jason W. ^{[1
]}

Tosh, Donna ^{[1
]}

Bergmann-Leitner, Elke ^{[1
]}

Paolino, Kristopher ^{[1
]}

Regules, Jason ^{[1
]}

Duncan, Elizabeth H. ^{[1
]}

Twomey, Patrick ^{[1
]}

Moon, James ^{[1
]}

Kathcart, April ^{[1
]}

Hosie, Heather E. ^{[1
]}

Storme, Casey K. ^{[1
]}

Spring, Michele ^{[1
]}

Hauns, Kevin ^{[1
]}

Komisar, Jack ^{[1
]}

Qabar, Aziz ^{[1
]}

Davidson, Silas ^{[1
]}

Ockenhouse, Christian F. ^{[2
]}

Vekemans, Johan ^{[3
]}

Soisson, Lorraine ^{[4
]}

Ballou, Ripley ^{[3
]}

Diggs, Carter ^{[4
]}

Waters, Norman C. ^{[1
]}

Paris, Robert M. ^{[1
]}

Angov, Evelina ^{[1
]}

机构：

[1] Walter Reed Army Inst Res, Silver Spring, MD USA

[2] PATH Malaria Vaccine Initiat, Washington, DC USA

[3] GlaxoSmithKline Vaccines, Rixenart, Belgium

[4] US Agcy Int Dev, Washington, DC 20523 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2015年 / 93卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

1278

引用

页码：391 / 391

页数：1

共 4 条

[1] PHASE 1A OPEN-LABEL DOSE ESCALATION STUDY TO EVALUATE THE SAFETY, REACTOGENICITY, AND IMMUNOGENICITY OF THE CANDIDATE PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP-142) ADMINISTERED INTRAMUSCULARLY WITH GSK BIOLOGICALS' ADJUVANT SYSTEM AS01B IN HEALTHY MALARIA-NAIVE ADULTS
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[3] A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naive adults
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[4] LONG TERM EFFICACY, SAFETY, REACTOGENICITY, AND IMMUNOGENICITY OF PHASE IIA, OPEN-LABEL, CONTROLLED STUDY FOR THE RTS, S/AS01B MALARIA VACCINE CANDIDATE ADMINISTERED AS STANDARD DOSES AT 0 AND 1 MONTHS AND 1/5TH STANDARD DOSE AT 7 MONTHS (DELAYED FRACTIONAL DOSE GROUP) AND ADMINISTERED AS THREE STANDARD DOSES ONE MONTH APART (0, 1, 2-MONTH GROUP) IN HEALTHY MALARIA-NAIVE VOLUNTEERS AGED 18-50 YEARS
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Paolino, Kristopher M.
Twomey, Patrick S.
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Kathcart, April K.
Hauns, Kevin D.
Komisar, Jack L.
Qabar, Aziz N.
Davidson, Silas A.
Griffith, Matthew E.
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Paris, Robert M.
Waters, Norman C.
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