Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration

被引：276

作者：

Nonoyama, Takayuki ^{[1
,2
]}

Wada, Susumu ^{[3
]}

Kiyama, Ryuji ^{[4
]}

Kitamura, Nobuto ^{[3
]}

Mredha, Md. Tariful Islam ^{[4
]}

Zhang, Xi ^{[5
]}

Kurokawa, Takayuki ^{[1
,2
]}

Nakajima, Tasuku ^{[1
,2
]}

Takagi, Yasuaki ^{[5
]}

Yasuda, Kazunori ^{[3
]}

Gong, Jian Ping ^{[1
,2
]}

机构：

[1] Hokkaido Univ, Fac Adv Life Sci, Sapporo, Hokkaido 0600810, Japan

[2] Hokkaido Univ, Global Stn Soft Matter, Global Inst Collaborat Res & Educ, Sapporo, Hokkaido 0600810, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Sports Med & Joint Surg, Sapporo, Hokkaido 0600810, Japan

[4] Hokkaido Univ, Grad Sch Life Sci, Sapporo, Hokkaido 0600810, Japan

[5] Hokkaido Univ, Fac Fisheries Sci, Hakodate, Hokkaido 0418611, Japan

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 31期

基金：

日本学术振兴会;

关键词：

HIGH-TOUGHNESS; HYDROXYAPATITE FORMATION; REGENERATION; STRENGTH;

D O I：

10.1002/adma.201601030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi-permeablility of the hydrogel. The gradient layer (around 40 mu m thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.

引用

页码：6740 / +

页数：7

共 27 条

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Buckwalter JA, 1998, ARTHRITIS RHEUM-US, V41, P1331, DOI 10.1002/1529-0131(199808)41:8<1331::AID-ART2>3.0.CO

[4]

2-J