The endocannabinoid signalling system: Biochemical aspects

被引：157

作者：

Bisogno, T ^{[1
]}

Ligresti, A ^{[1
]}

Di Marzo, V ^{[1
]}

机构：

[1] CNR, Ist Chim Biomol, Endocannabinoid Res Grp, I-80078 Pozzuoli, Napoli, Italy

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2005年 / 81卷 / 02期

关键词：

anandamide; 2-arachidonoylglycerol; cannabinoid receptors; anandamide transporter; fatty acid amide hydrolase;

D O I：

10.1016/j.pbb.2005.01.027

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Knowledge of the endogenous cannabinoid system has expanded greatly during the past years. After the discovery of the cannabinoid receptors, of their endogenous agonists and of the proteins for their synthesis and inactivation, significant progress has been made towards the understanding of the role of the endocannabinoid system in vital functions. Subsequently, an increasing number of papers has been published on the biochemistry and pharmacology of endocannabinoids. This article overviews the endocannabinoid signalling system with focus on its biochemical aspects. In particular we review the mechanisms for the biosynthesis and inactivation of the endocannabinoids, as well as the various molecular targets for some of the endocannabinoids described so far. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：224 / 238

页数：15

共 154 条

[41]

DEVANE WA, 1988, MOL PHARMACOL, V34, P605

[42] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR [J].

DEVANE, WA ;

HANUS, L ;

BREUER, A ;

PERTWEE, RG ;

STEVENSON, LA ;

GRIFFIN, G ;

GIBSON, D ;

MANDELBAUM, A ;

ETINGER, A ;

MECHOULAM, R .

SCIENCE, 1992, 258 (5090) :1946-1949

[43] Highly selective CB1 cannabinoid receptor ligands and novel CB1/VR1 vanilloid receptor "hybrid" ligands [J].

Di Marzo, V ;

Bisogno, T ;

De Petrocellis, L ;

Brandi, I ;

Jefferson, RG ;

Winckler, RL ;

Davis, JB ;

Dasse, O ;

Mahadevan, A ;

Razdan, RK ;

Martin, BR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 281 (02) :444-451

[44] Levels, metabolism, and pharmacological activity of anandamide in CB1 cannabinoid receptor knockout mice:: Evidence for non-CB1, non-CB2 receptor-mediated actions of anandamide in mouse brain [J].

Di Marzo, V ;

Breivogel, CS ;

Tao, Q ;

Bridgen, DT ;

Razdan, RK ;

Zimmer, AM ;

Zimmer, A ;

Martin, BR .

JOURNAL OF NEUROCHEMISTRY, 2000, 75 (06) :2434-2444

[45] A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid [J].

Di Marzo, V ;

Griffin, G ;

De Petrocellis, W ;

Brandi, I ;

Bisogno, T ;

Williams, W ;

Grier, MC ;

Kulasegram, S ;

Mahadevan, A ;

Razdan, RK ;

Martin, BR .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (03) :984-991

[46] Anandamide receptors [J].

Di Marzo, V ;

De Petrocellis, L ;

Fezza, F ;

Ligresti, A ;

Bisogno, T .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2002, 66 (2-3) :377-391

[47] Biochemistry of the endogenous ligands of cannabinoid receptors [J].

Di Marzo, V ;

Deutsch, DG .

NEUROBIOLOGY OF DISEASE, 1998, 5 (06) :386-404

[48] Anandamide: some like it hot [J].

Di Marzo, V ;

Bisogno, T ;

De Petrocellis, L .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (07) :346-349

[49] Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages [J].

Di Marzo, V ;

Bisogno, T ;

De Petrocellis, L ;

Melck, D ;

Orlando, P ;

Wagner, JA ;

Kunos, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (01) :258-267

[50] FORMATION AND INACTIVATION OF ENDOGENOUS CANNABINOID ANANDAMIDE IN CENTRAL NEURONS [J].

DIMARZO, V ;

FONTANA, A ;

CADAS, H ;

SCHINELLI, S ;

CIMINO, G ;

SCHWARTZ, JC ;

PIOMELLI, D .

NATURE, 1994, 372 (6507) :686-691

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