Expansion of CD56-Negative, CD16-Positive, KIR-Expressing Natural Killer Cells after T Cell-Depleted Haploidentical Hematopoietic Stem Cell Transplantation

被引：14

作者：

De Angelis, Claudia ^{[3
]}

Mancusi, Antonella ^{[3
]}

Ruggeri, Loredana ^{[3
]}

Capanni, Marusca ^{[3
]}

Urbani, Elena ^{[3
]}

Velardi, Andrea ^{[3
]}

Stern, Martin ^{[1
,2
]}

机构：

[1] Univ Basel Hosp, Div Hematol, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland

[3] Univ Perugia, Dept Clin & Expt Med, Div Hematol & Clin Immunol, I-06100 Perugia, Italy

来源：

ACTA HAEMATOLOGICA | 2011年 / 126卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Natural killer cells; Haploidentical hematopoietic stem cell transplantation; Acute myeloid leukemia; Graft-versus-leukemia effect; NK-CELLS; MISSING SELF; INHIBITORY RECEPTORS; PERIPHERAL-BLOOD; CLASS-I; LEUKEMIA; SUBSET; ALLOREACTIVITY; RECOGNITION; LIGANDS;

D O I：

10.1159/000323661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The main functions of natural killer (NK) cells are early protection against viruses or tumor cells and production of cytokines that regulate immune functions. The present study assessed the role of different NK subsets in exerting graft-versus-leukemia effects in recipients of human leukocyte antigen (HLA) haploidentical hematopoietic transplants and monitored for the first time CD3-/CD56- lymphocyte expansion. CD3-/CD56- cells expressed NK cell-associated molecules, such as CD16, NKp46, NKp30, CD244 (2B4), CD161, and killer cell immunoglobulin-like receptors. CD3-/CD56- cells further exhibited the classical functional characteristics of NK cells: cytolysis of target cells lacking HLA class I, antibody-dependent cellular cytotoxicity and cytokine production. These results demonstrate that CD56- NK cells are functional, recognize missing self and, like their CD56+ counterparts, may contribute to graft-versus-leukemia reactions. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：13 / 20

页数：8

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