A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action

被引：56

作者：

Yang, Jie ^{[1
,3
]}

Liu, Shuwen ^{[1
]}

Du, Lanying ^{[3
]}

Jiang, Shibo ^{[2
,3
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Key Lab New Drug Screening Guangdong Prov, Guangzhou, Guangdong, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China

[3] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA

来源：

REVIEWS IN MEDICAL VIROLOGY | 2016年 / 26卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ENTRY INHIBITORS; ADVISORY-COMMITTEE; ANTIVIRAL AGENTS; FUSION INHIBITOR; CATALYTIC SITE; SIALIC-ACID; OSELTAMIVIR; INFECTION; RESISTANCE; BINDING;

D O I：

10.1002/rmv.1879

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The entire life cycle of influenza virus involves viral attachment, entry, replication, and release. Previous studies have demonstrated that neuraminidase (NA) is an essential glycoprotein on the surface of influenza virus and that it is responsible for release of progeny virions from the host cell to infect new cells. However, recent studies have also suggested that NA may play other roles in the early stages of the viral life cycle, that is, viral attachment and entry. This review focuses on the new role of NA in the early stages of influenza life cycle and the corresponding development of novel NA inhibitors. Copyright (c) 2016 John Wiley & Sons, Ltd.

引用

页码：242 / 250

页数：9

共 70 条

[21] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[22] Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans [J].

Garten, Rebecca J. ;

Davis, C. Todd ;

Russell, Colin A. ;

Shu, Bo ;

Lindstrom, Stephen ;

Balish, Amanda ;

Sessions, Wendy M. ;

Xu, Xiyan ;

Skepner, Eugene ;

Deyde, Varough ;

Okomo-Adhiambo, Margaret ;

Gubareva, Larisa ;

Barnes, John ;

Smith, Catherine B. ;

Emery, Shannon L. ;

Hillman, Michael J. ;

Rivailler, Pierre ;

Smagala, James ;

de Graaf, Miranda ;

Burke, David F. ;

Fouchier, Ron A. M. ;

Pappas, Claudia ;

Alpuche-Aranda, Celia M. ;

Lopez-Gatell, Hugo ;

Olivera, Hiram ;

Lopez, Irma ;

Myers, Christopher A. ;

Faix, Dennis ;

Blair, Patrick J. ;

Yu, Cindy ;

Keene, Kimberly M. ;

Dotson, P. David, Jr. ;

Boxrud, David ;

Sambol, Anthony R. ;

Abid, Syed H. ;

George, Kirsten St. ;

Bannerman, Tammy ;

Moore, Amanda L. ;

Stringer, David J. ;

Blevins, Patricia ;

Demmler-Harrison, Gail J. ;

Ginsberg, Michele ;

Kriner, Paula ;

Waterman, Steve ;

Smole, Sandra ;

Guevara, Hugo F. ;

Belongia, Edward A. ;

Clark, Patricia A. ;

Beatrice, Sara T. ;

Donis, Ruben .

SCIENCE, 2009, 325 (5937) :197-201

[23] Site-directed mutagenesis of catalytic residues of influenza virus neuraminidase as an aid to drug design [J].

Ghate, AA ;

Air, GM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 258 (02) :320-331

[24] Human H3N2 Influenza Viruses Isolated from 1968 To 2012 Show Varying Preference for Receptor Substructures with No Apparent Consequences for Disease or Spread [J].

Gulati, Shelly ;

Smith, David F. ;

Cummings, Richard D. ;

Couch, Robert B. ;

Griesemer, Sara B. ;

George, Kirsten St. ;

Webster, Robert G. ;

Air, Gillian M. .

PLOS ONE, 2013, 8 (06)

[25]

Harper Scott A., 2005, Morbidity and Mortality Weekly Report, V54, P1

[26] Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections [J].

Hayden, FG ;

Osterhaus, ADME ;

Treanor, JJ ;

Fleming, DM ;

Aoki, FY ;

Nicholson, KG ;

Bohnen, AM ;

Hirst, HM ;

Keene, O ;

Wightman, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (13) :874-880

[27] Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets [J].

Herfst, Sander ;

Schrauwen, Eefje J. A. ;

Linster, Martin ;

Chutinimitkul, Salin ;

de Wit, Emmie ;

Munster, Vincent J. ;

Sorrell, Erin M. ;

Bestebroer, Theo M. ;

Burke, David F. ;

Smith, Derek J. ;

Rimmelzwaan, Guus F. ;

Osterhaus, Albert D. M. E. ;

Fouchier, Ron A. M. .

SCIENCE, 2012, 336 (6088) :1534-1541

[28] Influenza Viruses with Receptor-Binding N1 Neuraminidases Occur Sporadically in Several Lineages and Show No Attenuation in Cell Culture or Mice [J].

Hooper, Kathryn A. ;

Crowe, James E., Jr. ;

Bloom, Jesse D. .

JOURNAL OF VIROLOGY, 2015, 89 (07) :3737-3745

[29] A Mutant Influenza Virus That Uses an N1 Neuraminidase as the Receptor-Binding Protein [J].

Hooper, Kathryn A. ;

Bloom, Jesse D. .

JOURNAL OF VIROLOGY, 2013, 87 (23) :12531-12540

[30] Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance [J].

Hu, Yunwen ;

Lu, Shuihua ;

Song, Zhigang ;

Wang, Wei ;

Hao, Pei ;

Li, Jianhua ;

Zhang, Xiaonan ;

Yen, Hui-Ling ;

Shi, Bisheng ;

Li, Tao ;

Guan, Wencai ;

Xu, Lei ;

Liu, Yi ;

Wang, Sen ;

Zhang, Xiaoling ;

Tian, Di ;

Zhu, Zhaoqin ;

He, Jing ;

Huang, Kai ;

Chen, Huijie ;

Zheng, Lulu ;

Li, Xuan ;

Ping, Jie ;

Kang, Bin ;

Xi, Xiuhong ;

Zha, Lijun ;

Li, Yixue ;

Zhang, Zhiyong ;

Peiris, Malik ;

Yuan, Zhenghong .

LANCET, 2013, 381 (9885) :2273-2279

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