A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action

被引：56

作者：

Yang, Jie ^{[1
,3
]}

Liu, Shuwen ^{[1
]}

Du, Lanying ^{[3
]}

Jiang, Shibo ^{[2
,3
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Key Lab New Drug Screening Guangdong Prov, Guangzhou, Guangdong, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol MOE MOH, Shanghai, Peoples R China

[3] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA

来源：

REVIEWS IN MEDICAL VIROLOGY | 2016年 / 26卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ENTRY INHIBITORS; ADVISORY-COMMITTEE; ANTIVIRAL AGENTS; FUSION INHIBITOR; CATALYTIC SITE; SIALIC-ACID; OSELTAMIVIR; INFECTION; RESISTANCE; BINDING;

D O I：

10.1002/rmv.1879

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The entire life cycle of influenza virus involves viral attachment, entry, replication, and release. Previous studies have demonstrated that neuraminidase (NA) is an essential glycoprotein on the surface of influenza virus and that it is responsible for release of progeny virions from the host cell to infect new cells. However, recent studies have also suggested that NA may play other roles in the early stages of the viral life cycle, that is, viral attachment and entry. This review focuses on the new role of NA in the early stages of influenza life cycle and the corresponding development of novel NA inhibitors. Copyright (c) 2016 John Wiley & Sons, Ltd.

引用

页码：242 / 250

页数：9

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