Continuous Flow Ozonolysis in a Laboratory Scale Reactor

被引：104
作者：
Irfan, Muhammad
Glasnov, Toma N.
Kappe, C. Oliver [1 ]
机构：
[1] Karl Franzens Univ Graz, Christian Doppler Lab Microwave Chem CDLMC, A-8010 Graz, Austria
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 05期
关键词：
ORGANIC-COMPOUNDS; OZONE OXIDATION; MECHANISM; MICROREACTORS; OZONIDES; ALCOHOLS; ALKENES;
D O I：
10.1021/ol102984h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several important types of ozonolysis reactions have been performed in a continuous flow device that is able to perform both the ozonolysis and quenching steps in flow mode. This technique allows safe and scalable ozonolysis reactions to be performed on a laboratory scale.
引用
收藏
页码：984 / 987
页数：4
相关论文
共 45 条
[1]   The Development of Continuous Process for Alkene Ozonolysis Based on Combined in Situ FTIR, Calorimetry, and Computational Chemistry [J].
Allian, Ayman D. ;
Richter, Steve M. ;
Kallemeyn, Jeffrey M. ;
Robbins, Timothy A. ;
Kishore, Vimal .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (01) :91-97
[2]   OZONE OXIDATION OF PRIMARY AMINES TO NITROALKANES [J].
BACHMAN, GB ;
STRAWN, KG .
JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (01) :313-&
[3]   THE REACTIONS OF OZONE WITH ORGANIC COMPOUNDS [J].
BAILEY, PS .
CHEMICAL REVIEWS, 1958, 58 (05) :925-1010
[4]  
BAILEY PS, 1978, OZONOLYSIS ORGANIC C, V1
[5]  
BAILEY PS, 1982, OZONOLYSIS ORGANIC C, V2
[6]   HYDROBORATION .85. SYNTHESIS AND HYDROBORATION OF (-)-2-PHENYLAPOPINENE - COMPARISON OF MONO(2-PHENYLAPOISOPINOCAMPHEYL)BORANE WITH ITS 2-METHYL AND 2-ETHYL ANALOGS FOR THE CHIRAL HYDROBORATION OF REPRESENTATIVE ALKENES [J].
BROWN, HC ;
WEISSMAN, SA ;
PERUMAL, PT ;
DHOKTE, UP .
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (04) :1217-1223
[7]   PREPARATION, PROPERTIES, AND REACTIONS OF CARBONYL OXIDES [J].
BUNNELLE, WH .
CHEMICAL REVIEWS, 1991, 91 (03) :335-362
[8]   OZONOLYSIS OF CERTAIN ACETYLENIC ALCOHOLS [J].
CANNON, JG ;
DARKO, LL .
JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (11) :3419-&
[9]   Large-scale oxidations in the pharmaceutical industry [J].
Caron, Stephane ;
Dugger, Robert W. ;
Ruggeri, Sally Gut ;
Ragan, John A. ;
Ripin, David H. Brown .
CHEMICAL REVIEWS, 2006, 106 (07) :2943-2989
[10]   MECHANISM OF OZONOLYSIS [J].
CRIEGEE, R .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1975, 14 (11) :745-752
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