Genome-virome interactions: examining the role of common viral infections in complex disease

被引：99

作者：

Foxman, Ellen F. ^{[1
]}

Iwasaki, Akiko ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY-TRACT INFECTIONS; BRONCHIAL EPITHELIAL-CELLS; INDUCED DIABETES-MELLITUS; INNATE IMMUNE-RESPONSE; CROHNS-DISEASE; RHINOVIRUS INFECTIONS; WIDE ASSOCIATION; ENDOGENOUS RETROVIRUSES; ENTEROVIRUS INFECTIONS; ULCERATIVE-COLITIS;

D O I：

10.1038/nrmicro2541

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

New technologies have widened our view of 'complex diseases': those with both genetic and environmental risk factors. In this Review, we explore recent genetic and virological evidence implicating host-virus interactions in three diseases: type 1 diabetes, inflammatory bowel disease and asthma. The viruses implicated in these diseases cause mucosal infections that affect most of the population but are asymptomatic or mild in many hosts. These findings place a new emphasis on common viral infections as important environmental factors in the pathogenesis of complex diseases, and they compel the field to pursue a better understanding of host interactions with the human virome.

引用

页码：254 / 264

页数：11

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