circRNA-miRNA-mRNA in breast cancer

被引：145

作者：

Zhang, Meilan ^{[1
]}

Bai, Xue ^{[1
]}

Zeng, Xuemei ^{[1
]}

Liu, Jiangrong ^{[1
]}

Liu, Feng ^{[1
]}

Zhang, Zhiwei ^{[1
]}

机构：

[1] Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2021年 / 523卷

关键词：

circRNA; miRNA; mRNA; Breast cancer; TUMOR-SUPPRESSOR; OVARIAN-CANCER; CIRCULAR RNAS; PROGRESSION; INVASION; PROMOTES; PROLIFERATION; MIGRATION; CELLS; RECEPTOR;

D O I：

10.1016/j.cca.2021.09.013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Among cancers, breast cancer has the highest incidence rate among women and poses a tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and circular RNA (circRNA) play vital roles in the progression of breast cancer through a variety of biological effects and mechanisms. Recently, the regulatory network formed by circRNAs, miRNAs and mRNAs has piqued attention and garnered interest. CircRNAs bind to miRNAs through a regulatory mechanism in which endogenous RNAs compete to indirectly regulate the expression of mRNA corresponding to downstream target genes of miRNAs, contributing to the progression of breast cancer. The circRNA-miRNA-mRNA axis may be a marker for the early diagnosis and prognosis of breast cancer and a potential breast cancer treatment target, providing unlimited possibilities for the development of breast cancer biomarkers and therapeutic strategies. This article reviews recent research progress on the circRNA-miRNA-mRNA axis as a regulatory network of competing endogenous RNAs in breast cancer. Herein, we focus on the mechanism and function of the circRNA-miRNA-mRNA axis in the occurrence and metastasis of breast cancer, and resistance to chemotherapy.

引用

页码：120 / 130

页数：11

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