Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

被引：46

作者：

Li, Zeyu ^{[1
]}

Ni, Jiatong ^{[1
]}

Liu, Liping ^{[2
]}

Gu, Liyuan ^{[3
]}

Wu, Zhiguang ^{[4
]}

Li, Tianlong ^{[4
]}

Ivanovich, Krasnyuk Ivan ^{[4
]}

Zhao, Wancheng ^{[1
]}

Sun, Tiedong ^{[1
]}

Wang, Ting ^{[1
]}

机构：

[1] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Engn Res Ctr Forest Biopreparat, Key Lab Forest Plant Ecol,Minist Educ, Harbin 150040, Peoples R China

[2] Harbin First Specialist Hosp, Harbin 150056, Peoples R China

[3] Henan Agr Univ, Coll Forestry, Zhengzhou 450002, Peoples R China

[4] Sechenov Univ, Inst Pharm, Moscow 119991, Russia

来源：

ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 25期

基金：

中国国家自然科学基金;

关键词：

polydopamine-based carbon dots; fluorescence imaging; cancer therapy; chemo-photothermal synergistic therapy; tumor-targeted delivery; imaging guiding; CELL ADHESION MOLECULE; DRUG-DELIVERY; CANCER; NANOPARTICLES; POPULATION; GRAPHENE; SYSTEM;

D O I：

10.1021/acsami.1c05079

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.

引用

页码：29340 / 29348

页数：9

共 31 条

[1]

[Anonymous], DICT PHARM MED, DOI DOI 10.1007/978-3-211-89836-9_140

[2] Tumor-Targeting Peptide for Redox-Responsive Pt Prodrug and Gene Codelivery and Synergistic Cancer Chemotherapy [J].

Bai, Yaxuan ;

Li, Zeyu ;

Liu, Liping ;

Sun, Tiedong ;

Fan, Xiaocheng ;

Wang, Ting ;

Gou, Zhenzhen ;

Tan, Shengnan .

ACS APPLIED BIO MATERIALS, 2019, 2 (04) :1420-1426

[3] Facile One-Pot Synthesis of Polydopamine Carbon Dots for Photothermal Therapy [J].

Bai, Yuting ;

Zhang, Bai ;

Chen, Lu ;

Lin, Zhenjie ;

Zhang, Xiuming ;

Ge, Dongtao ;

Shi, Wei ;

Sun, Yanan .

NANOSCALE RESEARCH LETTERS, 2018, 13

[4] Global cancer transitions according to the Human Development Index (2008-2030): a population-based study [J].

Bray, Freddie ;

Jemal, Ahmedin ;

Grey, Nathan ;

Ferlay, Jacques ;

Forman, David .

LANCET ONCOLOGY, 2012, 13 (08) :790-801

[5] Near-Infrared Light-Activatable Microneedle System for Treating Superficial Tumors by Combination of Chemotherapy and Photothermal Therapy [J].

Chen, Mei-Chin ;

Lin, Zhi-Wei ;

Ling, Ming -Hung .

ACS NANO, 2016, 10 (01) :93-101

[6]

Cheng L, 2011, NANOMEDICINE-UK, V6, P1327, DOI [10.2217/nnm.11.56, 10.2217/NNM.11.56]

[7] Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides [J].

Choi, Moon-Jeong ;

Pierson, R. ;

Chang, Yongmin ;

Guo, Haiquing ;

Kang, Inn-Kyu .

JOURNAL OF NANOMATERIALS, 2013, 2013

[8] Radiometals for Combined Imaging and Therapy [J].

Cutler, Cathy S. ;

Hennkens, Heather M. ;

Sisay, Nebiat ;

Huclier-Markai, Sandrine ;

Jurisson, Silvia S. .

CHEMICAL REVIEWS, 2013, 113 (02) :858-883

[9] Charge-Convertible Carbon Dots for Imaging Guided Drug Delivery with Enhanced in Vivo Cancer Therapeutic Efficiency [J].

Feng, Tao ;

Ai, Xiangzhao ;

An, Guanghui ;

Yang, Piaoping ;

Zhao, Yanli .

ACS NANO, 2016, 10 (04) :4410-4420

[10] Laser-induced interstitial thermotherapy of liver metastases in an interventional 0.5 tesla MRI system:: Technique and first clinical experiences [J].

Fiedler, VU ;

Schwarzmaier, HJ ;

Eickmeyer, F ;

Müller, FP ;

Schoepp, C ;

Verreet, PR .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2001, 13 (05) :729-737

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