Modeling prenatal opioid exposure in animals: Current findings and future directions

被引：66

作者：

Byrnes, Elizabeth M. ^{[1
]}

Vassoler, Fair M. ^{[1
]}

机构：

[1] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2018年 / 51卷

基金：

美国国家卫生研究院;

关键词：

Morphine; Methadone; Buprenorphine; Oxycodone; Postnatal; Transgenerational; Development; Mu receptor; HPA; NEONATAL ABSTINENCE SYNDROME; PITUITARY-ADRENAL AXIS; INTERMEDIATE MEDIAL MESOPALLIUM; ACOUSTIC STARTLE AMPLITUDE; LATERAL PERFORANT PATH; REST-ACTIVITY CYCLE; PROTEIN-KINASE-C; ADULT MALE RATS; MORPHINE EXPOSURE; SYNAPTIC PLASTICITY;

D O I：

10.1016/j.yfrne.2017.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The past decade has seen a drastic rise in the number of infants exposed to opioids in utero. It is unclear what lasting effect this exposure may have on these children. Animal models of prenatal opioid exposure may provide insight into potential areas of vulnerability. The present review summarizes the findings across animal models of prenatal opioid exposure, including exposure to morphine, methadone, buprenorphine, and oxycodone. Details regarding the drug, doses, and duration of treatment, as well as key findings, are summarized in tables with associated references. Finally, significant gaps in the current preclinical literature and future directions are discussed.

引用

页码：1 / 13

页数：13

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