Aging and cancer: are sirtuins the link?

被引：12

作者：

Rodriguez, Ramon M. ^{[1
,2
]}

Fraga, Mario F. ^{[2
]}

机构：

[1] CSIC, CNB, Dept Immunol & Oncol, Plaza Murillo 2, E-28049 Madrid, Spain

[2] Univ Oviedo, HUCA, IUOPA, Canc Epigenet Lab, Oviedo, Spain

来源：

FUTURE ONCOLOGY | 2010年 / 6卷 / 06期

关键词：

aging; cancer; epigenetics; sirtuins; stress; DNA-DAMAGE RESPONSE; LIFE-SPAN; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; HISTONE DEACETYLASE; GENE-EXPRESSION; CELL-SURVIVAL; SIR2; HOMOLOG; ACETYLATION CONTROLS; GENOMIC STABILITY;

D O I：

10.2217/FON.10.57

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Classically, aging has been defined as a general degeneration process that leads to the loss of corporal function. The loss of function caused by degeneration limits the maximum lifespan of all organisms and is linked to disease and cancer. Nevertheless, the molecular mechanisms behind aging and their connection to cancer are not well understood. NAD-dependent protein deacetylase enzymes, sirtuins, are emerging as a novel molecular link between aging and cancer due to their specific role in cell cycle regulation, antistress response and cell survival. This article reviews the contribution of sirtuins and environmental factors to ontogenic development, senescence and cancer.

引用

页码：905 / 915

页数：11

共 108 条

[1] SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways [J].

Allison, Simon J. ;

Milner, Jo .

CELL CYCLE, 2007, 6 (21) :2669-2677

[2] SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription [J].

Amat, Ramon ;

Solanes, Gemma ;

Giralt, Marta ;

Villarroya, Francesc .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (47) :34066-34076

[3] The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet [J].

Arum, Oge ;

Bonkowski, Michael S. ;

Rocha, Juliana S. ;

Bartke, Andrzej .

AGING CELL, 2009, 8 (06) :756-760

[4] Altered sirtuin expression is associated with node-positive breast cancer [J].

Ashraf, N. ;

Zino, S. ;

MacIntyre, A. ;

Kingsmore, D. ;

Payne, A. P. ;

George, W. D. ;

Shiels, P. G. .

BRITISH JOURNAL OF CANCER, 2006, 95 (08) :1056-1061

[5] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[6] Longevity - Extending the lifespan of long-lived mice [J].

Bartke, A ;

Wright, JC ;

Mattison, JA ;

Ingram, DK ;

Miller, RA ;

Roth, GS .

NATURE, 2001, 414 (6862) :412-412

[7]

Baur J.A., 2009, BIOCH BIOPHYS ACTA

[8] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[9] C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span [J].

Berdichevsky, Ala ;

Viswanathan, Mohan ;

Horvitz, H. Robert ;

Guarente, Leonard .

CELL, 2006, 125 (06) :1165-1177

[10]

BERDYSHEV G. D., 1967, BIOKHIMIYA, V32, P988

← 1 2 3 4 5 6 7 8 9 10 →