Anti N-methyl-D-aspartate receptor encephalitis: a game-changer?

被引：8

作者：

Fischer, Corinne E. ^{[1
,2
,3
]}

Golas, Angela C. ^{[4
]}

Schweizer, Tom A. ^{[1
,2
,5
,6
,7
]}

Munoz, David G. ^{[1
,8
,9
]}

Ismail, Zahinoor ^{[10
]}

Qian, Winnie ^{[1
,2
]}

Tang-Wai, David F. ^{[11
,12
]}

Rotstein, Dalia L. ^{[13
]}

Day, Gregory S. ^{[14
]}

机构：

[1] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Res, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] Univ Toronto, Fac Med, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

[6] Univ Toronto, Fac Med, Dept Surg, Div Neurosurg, Toronto, ON, Canada

[7] St Michaels Hosp, Div Neurosurg, Toronto, ON, Canada

[8] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[9] St Michaels Hosp, Dept Lab Med & Pathobiol, Div Pathol, Toronto, ON, Canada

[10] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[11] Univ Toronto, Dept Med Neurol & Geriatr Med, Toronto, ON, Canada

[12] Toronto Western Hosp, UHN Memory Clin, Toronto, ON, Canada

[13] Univ Toronto, St Michaels Hosp, Dept Med Neurol, Toronto, ON, Canada

[14] Washington Univ, Dept Neurol, Knight Alzheimer Dis Res Ctr, St Louis, MO USA

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2016年 / 16卷 / 07期

关键词：

NMDA receptor; encephalitis; psychosis; delusions; hallucinations; HERPES-SIMPLEX ENCEPHALITIS; THERAPEUTIC PLASMA-EXCHANGE; AUTOIMMUNE LIMBIC ENCEPHALITIS; EXTREME DELTA BRUSH; NMDA-RECEPTOR; OVARIAN TERATOMA; CASE SERIES; PARANEOPLASTIC ENCEPHALITIS; PSYCHIATRIC PRESENTATION; ANTIBODIES ENCEPHALITIS;

D O I：

10.1080/14737175.2016.1184088

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an inflammatory disorder of the brain that has garnered significant interest within the medical and lay communities. There is a need for formal guidelines to assist physicians in identifying patients who should undergo testing for NMDAR encephalitis, recognizing the high potential for this potentially treatable disease to mimic more common disorders, and consequently remain undiagnosed. Areas covered: This review highlights the impact of the discovery of NMDAR encephalitis on the fields of neurology and psychiatry, and discusses the steps that are necessary to improve recognition and treatment of NMDAR encephalitis. Expert commentary: While much progress has been made in our understanding of NMDAR encephalitis, much work remains to be done to delineate the underlying disease mechanisms and their relevance to brain function.

引用

页码：849 / 859

页数：11

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