Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis

被引：0

作者：

Nassonov, EL

Samsonov, MY

Tilz, GP

Chichasova, NV

Widner, B

Demel, U

Nikiphorova, EL

Fuchs, D

机构：

[1] Moscow Med Acad, Dept Rheumatol, Moscow, Russia

[2] Graz Univ, Dept Internal Med, Graz, Austria

[3] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria

来源：

PTERIDINES | 2000年 / 11卷 / 02期

关键词：

rheumatoid arthritis; soluble cytokine receptors; neopterin;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum concentrations of soluble intercellular adhesion molecules, sICAM-1, sICAM-3 and sP-selectin, of serum soluble cytokine receptors, sIL-2R, and sTNF-R55 and of neopterin were measured by commercially available immunoassays in 35 patients with rheumatoid arthritis (RA). Serum sICAM-1, sICAM-3 and sP-selectin were significantly elevated in patients with RA compared with healthy controls. Concentrations of sP-selectin and sICAM-3 correlated with disease activity and severity indices. sICAM-3 levels significantly correlated with sTNF-R55 and neopterin. There were significant correlations between neopterin and sIL-2R and between sTNF-R55 and sIL-2R. The measurement of sP-selectin and sICAM-3 levels in patients with RA might become useful for monitoring disease activity.

引用

页码：54 / 59

页数：6

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