Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes

被引：36

作者：

Eto, Kazuhiro ^{[1
,2
]}

Tumenbayar, Bayasgalan ^{[2
]}

Nagashima, Shu-ichi ^{[2
]}

Tazoe, Fumiko ^{[2
]}

Miyamoto, Michiaki ^{[2
]}

Takahashi, Manabu ^{[2
]}

Ando, Akihiko ^{[2
]}

Okada, Kenta ^{[2
]}

Yagyu, Hiroaki ^{[2
]}

Ishibashi, Shun ^{[2
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Internal Med, Itabashi Ku, Tokyo 1738605, Japan

[2] Jichi Med Univ, Dept Med, Div Endocrinol & Metab, Shimotsuke, Tochigi 3290498, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2010年 / 89卷 / 01期

关键词：

FGF21; Adiponectin; Type; 2; diabetes; ACTIVATED-RECEPTOR-GAMMA; PPAR-ALPHA; FIBROBLAST-GROWTH-FACTOR-21; MELLITUS; FGF-21; IDENTIFICATION; METABOLISM; REGULATOR; DISEASES; KLOTHO;

D O I：

10.1016/j.diabres.2010.03.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor 21 (FGF21) has been identified as a novel metabolic regulator. This cross-sectional study was performed to clarify how serum FGF21 levels were associated with clinical parameters in Japanese subjects with type 2 diabetes (n = 139). Anthropometric and blood biochemical parameters, uses of drugs for diabetes, hypertension and dyslipidemia were examined regarding associations with fasting serum FGF21 concentrations. FGF21 levels were 6-times higher in those subjects taking fibrates. However, a use of thiazolidinediones did not affect serum FGF21 levels while it induced higher serum adiponectin levels. In univariate analyses, FGF21 levels showed associations with a use of fibrates, triglyceride levels, creatinine levels, waist circumference, and BMI. Multiple regression analyses adjusted for age, gender and BMI showed that a use of fibrates, triglyceride levels and creatinine levels were strong contributors to serum FGF21 levels. In contrast, a use of thiazolidinediones, HDL-cholesterol levels and fasting insulin levels were strong contributors to serum adiponectin levels. This study revealed that serum FGF21 levels were biochemical indicators correlating to a set of essential metabolic parameters, which was distinct from that correlating to serum adiponectin levels in subjects with type 2 diabetes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 57

页数：6

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