ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery

被引：27

作者：

Zhao, Meihui ^{[1
]}

Zhang, Yu ^{[1
]}

Yuan, Shirui ^{[1
]}

Xu, Xiang ^{[1
]}

Wu, Ziheng ^{[2
]}

Wu, Zhenghong ^{[1
]}

Qi, Xiaole ^{[1
]}

机构：

[1] China Pharmaceut Univ, Key Lab Modern Chinese Medicines, Nanjing 210009, Jiangsu, Peoples R China

[2] Monash Univ, Parkville Campus, Parkville, Vic 3052, Australia

来源：

SOFT MATTER | 2019年 / 15卷 / 18期

基金：

中国国家自然科学基金;

关键词：

HYDROGEL; RELEASE;

D O I：

10.1039/c9sm00480g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.

引用

页码：3655 / 3658

页数：4

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